{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:14:37Z","timestamp":1788412477957,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Users of semaglutide for weight management (SEMA\u2010WM) may not follow the recommended treatment regimen. We investigated SEMA\u2010WM treatment patterns among Danish adult users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A questionnaire\u2010based survey was conducted across 28 Danish community pharmacies between March and May 2025. Adults redeeming a SEMA\u2010WM prescription were invited to participate, with first\u2010time users invited to a follow\u2010up survey after 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1470 individuals invited, 767 (52%) completed the questionnaire. Forty\u2010five percent used 1\u2009mg as their current dose, and 8% expected to reach 2.4\u2009mg. Ten percent reported dosing SEMA\u2010WM by \u201ccounting clicks\u201d on the injection pen, in contrast with official prescribing guidelines. Users treated for 1\u20133\u2009months reported a median weight loss of 6% (IQR 3\u20137), increasing to 12% (IQR 9\u201314), 17% (IQR 12\u201321), and 20% (IQR 15\u201326) for those treated for 3\u20136\u2009months, 6\u201312\u2009months, and &gt;\u20091\u2009year, respectively. Weight loss by treatment duration was similar among 1\u2009mg users. Twenty\u2010four percent reported reduced\/discontinued concomitant medication use following SEMA\u2010WM initiation, especially for muscle\/joint pain (30%) and antihypertensives (24%). Reduced\/discontinued medication use was similar among 1\u2009mg users. Among 42 first\u2010time users, 83% were still using SEMA\u2010WM after 6 months, usually 1\u2009mg (60%). Among users who had discontinued treatment (17%), side effects were the most reported reason.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Many SEMA\u2010WM users remained on 1\u2009mg and reported weight loss and medication reductions similar to the overall cohort. Findings indicate that some users appear to obtain the desired effect at 1\u2009mg, underscoring the need for better guidance on individualized treatment trajectories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71099","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:57:46Z","timestamp":1783997866000},"page":"8955-8965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Patterns and Experienced Effects of Semaglutide for Weight Management Among Adult Users in Denmark: A Community Pharmacy\u2010Based Cross\u2010Sectional Survey"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3387-4685","authenticated-orcid":false,"given":"Katrine","family":"Kj\u00e6rgaard","sequence":"first","affiliation":[{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"},{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-3107","authenticated-orcid":false,"given":"Trine","family":"Graab\u00e6k","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3474","authenticated-orcid":false,"given":"Reimar W.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-6263","authenticated-orcid":false,"given":"Lise Gehrt","family":"Card\u00e9l","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8782-1511","authenticated-orcid":false,"given":"Maja","family":"Bramming","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"},{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-6252","authenticated-orcid":false,"given":"Carina","family":"Lundby","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"},{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16291"},{"key":"e_1_2_9_3_1","unstructured":"U.S. Food & Drug WEGOVY (Semaglutide) Injection for Subcutaneous use Initial U.S. Approval: 2017(2021) accessed September 15 2025 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/215256s000lbl.pdf."},{"key":"e_1_2_9_4_1","unstructured":"Medicin.dk Wegovy Flextouch \u2013 Information Til Sundhedsfaglige \u2013 Medicin.dk accessed April 29 2025 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