{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:56Z","timestamp":1792471136376,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Automated insulin delivery (AID) systems improve glycaemic outcomes in Type 1 diabetes; however, paediatric real\u2010world data on newly introduced tubeless AID systems remain limited. We aimed to provide the first clinical evaluation of the A8 TouchCare Nano AID system with the APGO algorithm in children and adolescents with Type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, children and adolescents initiating TouchCare Nano AID therapy were followed for 6\u2009months. Continuous glucose monitoring metrics were assessed at baseline and 1, 3 and 6\u2009months. The primary outcome was change in time in range (TIR, 70\u2013180\u2009mg\/dL). Secondary outcomes included time in tight range (TiTR, 70\u2013140\u2009mg\/dL), time above and below range, glucose variability, insulin dose, achievement of ISPAD glycaemic targets and safety. HbA1c was measured at baseline, 3 and 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010six participants (mean age 13.3\u2009\u00b1\u20093.2\u2009years) completed follow\u2010up. Mean TIR increased from 59.0%\u2009\u00b1\u200915.6% at baseline to 74.2%\u2009\u00b1\u20098.9% at 1\u2009month and remained significantly higher at 3 and 6\u2009months (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). TiTR significantly improved, whilst time above range decreased and time below range remained stable. More than half of participants achieved the ISPAD target of TIR &gt;\u200970% at 6\u2009months. Mean sensor glucose and glucose variability declined, and HbA1c decreased from 7.4%\u2009\u00b1\u20090.8% to 6.9%\u2009\u00b1\u20090.7% at 3 and 6\u2009months (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No episodes of severe hypoglycaemia or diabetic ketoacidosis were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In routine paediatric care, use of this tubeless AID system was associated with rapid and sustained improvements in glycaemic control without increased hypoglycaemia.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      : NCT07425912.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71101","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:30:47Z","timestamp":1784799047000},"page":"9275-9283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Effectiveness and Safety of a Tubeless Automated Insulin Delivery System With an Adaptive Control Algorithm (\n                    <scp>APGO<\/scp>\n                    ) in Children and Adolescents With Type 1 Diabetes: A Multicentre Observational Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-1321","authenticated-orcid":false,"given":"Angela","family":"Zanfardino","sequence":"first","affiliation":[{"name":"Regional Centre for Pediatric Diabetes, Department of Pediatrics University of the Study of Campania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Iafusco","sequence":"additional","affiliation":[{"name":"Regional Centre for Pediatric Diabetes, Department of Pediatrics University of the Study of Campania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Ippolito","sequence":"additional","affiliation":[{"name":"Regional Centre for Pediatric Diabetes, Department of Pediatrics University of the Study of Campania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele Miraglia","family":"del Giudice","sequence":"additional","affiliation":[{"name":"Regional Centre for Pediatric Diabetes, Department of Pediatrics University of the Study of Campania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta Serena","family":"Rollato","sequence":"additional","affiliation":[{"name":"Regional Centre for Pediatric Diabetes, Department of Pediatrics University of the Study of Campania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Chianese","sequence":"additional","affiliation":[{"name":"Regional Centre for Pediatric Diabetes, Department of Pediatrics University of the Study of Campania  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Figuccia","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Toni","sequence":"additional","affiliation":[{"name":"Diabetology Unit Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa Giulia","family":"Ferlito","sequence":"additional","affiliation":[{"name":"Diabetology Unit Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Piccini","sequence":"additional","affiliation":[{"name":"Diabetology Unit Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2025.05.752"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3310\/JYPL3536"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109858"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20100172"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0578"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20102359"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0337"},{"key":"e_1_2_11_9_1","unstructured":"Medtrum Technologies Inc. \u201cTouchCare Nano System \u201daccessed\u00a0February 14 2026 https:\/\/www.medtrum.com\/product\/nanosystem.html."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16070944"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0289684"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010025\u201002589\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2026.05.004"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000543266"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2025.2740"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20102311"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589\u20107500(22)00020\u20106"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681100500403"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968211022321"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.13994"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u20101768"},{"key":"e_1_2_11_22_1","unstructured":"INFARMED\u2014Autoridade Nacional do Medicamento e Produtos de Sa\u00fade \u201cSistema de Monitoriza\u00e7\u00e3o da Glicose do fabricante Medtrum Technologies Inc. Circular Informativa No 006\/CD\/550.20.001 de 10\/02\/2025 \u201daccessed May 12 2026 INFARMED Safety Notice."},{"key":"e_1_2_11_23_1","unstructured":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (AEMPS) \u201cLa AEMPS informa del cese de comercializaci\u00f3n y retirada del mercado del sensor y transmisor del sistema de monitorizaci\u00f3n continua de glucosa A8 TouchCare \u201daccessed May 12 2026 AEMPS Safety Notice."},{"key":"e_1_2_11_24_1","unstructured":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) \u201cD\u00e9cision de police sanitaire du 28\/01\/2026\u2014Medtrum Technologies Inc \u201daccessed May 12 2026 ANSM Regulatory Decision."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231178525"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14962"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:51:55Z","timestamp":1792468315000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/dom.71101"],"URL":"https:\/\/doi.org\/10.1111\/dom.71101","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71101\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71101\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}