{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:53Z","timestamp":1792471133991,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013108"],"award-info":[{"award-number":["2024A1515013108"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573391"],"award-info":[{"award-number":["82573391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Body mass index (BMI) is associated with multisystem disease risk, but the immune cell\u2010specific regulatory contexts underlying BMI\u2010related genetic associations with disease outcomes remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We applied a cell\u2010stratified Mendelian randomization framework integrating European\u2010ancestry BMI GWAS data, GWAS datasets for 33 disease outcomes across five disease systems, single\u2010cell cis\u2010eQTL data from 28 peripheral blood immune cell types, and dynamic CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell eQTL data. SuSiE\u2010based colocalization was used to identify BMI\u2010associated loci sharing causal variants with immune\u2010cell gene expression. These variants were used as cell\u2010stratified instruments for Mendelian randomization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across 28 immune cell types, 1326 colocalized variants regulating 1426 genes were identified. In primary MR analyses, genetically predicted BMI showed Bonferroni\u2010significant associations with 26 disease outcomes. Cell\u2010stratified analyses identified 87 Bonferroni\u2010significant associations across 17 disease outcomes. Cardiovascular diseases showed the broadest cell\u2010stratified associations, followed by respiratory and metabolic diseases. CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell regulatory contexts contributed one of the largest shares of prioritized associations, and BMI\u2010related effects varied across CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell activation states. Cross\u2010disease prioritization highlighted recurrent immune feature genes, including TRAF3 and FGFR1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings prioritize CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell regulatory contexts as potential immunogenetic links between BMI and multi\u2010system disease risk, while requiring further validation in diverse populations and mechanistic models.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71105","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:07:34Z","timestamp":1783998454000},"page":"8974-8991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Cell\u2010Stratified Regulatory Contexts Associated With\n                    <scp>BMI<\/scp>\n                    \u2010Related Multi\u2010System Disease Risk: A Cell\u2010Stratified Mendelian Randomization Study Using Single\u2010Cell\n                    <scp>eQTL<\/scp>\n                    Data"],"prefix":"10.1111","volume":"28","author":[{"given":"Kai","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6931-2846","authenticated-orcid":false,"given":"Yitong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meishan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashuo","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuming","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"Functional Experimental Teaching Center, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12122046"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.70125"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010023\u201000847\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14520"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2026.106702"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19897"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1701944"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009686\u20105"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.675018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010022\u201005725\u20102"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049263\u20104"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001066\u20103"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.03.20.25324352"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy271"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005473\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100407\u2010x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009440"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn6598"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15555.3"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040501"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt179"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0029665112000092"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci57132"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.115.010207"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci92035"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(22)00033\u2010x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.116.026560"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab368"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/nss.S422917"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14824"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010022\u201001222\u20104"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1022361"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23\u20100970"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.120.316203"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010023\u201000908\u20102"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.19769"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010019\u20100110\u20102"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v14.i9.887"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010025\u201003994\u2010w"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01173"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1044737"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2001"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2353"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.056"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004713\u20101"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf3041"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053621\u20107"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1021524"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00470.2014"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.962561"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201002677\u20109"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.05.030"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.23878"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.20960\/nh.05893"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v32.i12.115990"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1624878"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:51:44Z","timestamp":1792468304000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/dom.71105"],"URL":"https:\/\/doi.org\/10.1111\/dom.71105","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71105\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71105\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"2026-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}