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This study aims to assess their effects on seated\u2010 and ambulatory BP (ABP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase and the Cochrane Library were searched for randomised controlled trials reporting systolic BP (SBP), diastolic BP (DBP) or ABP. Placebo\u2010controlled and active\u2010controlled comparisons were analysed separately. Subgroup and meta\u2010regression analysis were prespecified as exploratory. Risk of bias and certainty of evidence were assessed using the Cochrane tool and GRADE, respectively. The protocol was registered in PROSPERO (CRD42019138927).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010seven publications comprising 79 studies were included and only 11 studies were rated as high quality. Compared with placebo, DPP\u20104i produced a small reduction in seated SBP (\u22121.69\u2009mmHg; 95% CI, \u22122.78 to \u22120.61,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200918%; 26 studies;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092587 participants). In the exploratory renin\u2010angiotensin\u2010aldosterone system inhibitors\u00a0(RAASi) co\u2010administration subgroup, seated SBP was lower by \u22121.60\u2009mmHg (95% CI, \u22123.04 to \u22120.16;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200957%; 39 studies;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094064 participants), with moderate heterogeneity. In participants with baseline HbA1c \u2264\u20097.5%, the DBP estimate was borderline (\u22120.85\u2009mmHg; 95% CI, \u22121.71 to 0.00; 22 studies;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091655 participants) and was not considered robust evidence of benefit. High\u2010quality studies showed no detectable changes in seated SBP or DBP. ABP analyses showed no detectable differences based on only three publications (four studies). Estimates were exploratory and underpowered and certainty was low to very low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DPP\u20104i might produce a small reduction in seated SBP compared with placebo, but the magnitude was modest and the clinical relevance for individual patients was uncertain. Evidence for DBP and ABP effects was inconclusive. These findings did not support the use of DPP\u20104i as BP\u2010lowering therapy, and adequately powered trials with standardised BP protocols are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71107","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:06:08Z","timestamp":1784106368000},"page":"9014-9028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of\n                    <scp>DPP<\/scp>\n                    \u20104 Inhibitors on Seated and Ambulatory Blood Pressure in Type 2 Diabetes Mellitus"],"prefix":"10.1111","volume":"28","author":[{"given":"Lijia","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Tiantan Hospital, Capital Medical University  Beijing 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