{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:24Z","timestamp":1792384884568,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Limited data on the link between various measures of glycemia and metabolism and autonomic dysfunction exist. We assessed the association of fasting plasma glucose [FPG], glycated haemoglobin [HbA\n                      <jats:sub>1C<\/jats:sub>\n                      ], fasting insulin, and HOMA\u2010IR and cardiac autonomic function measures separately for men and women in the Diabetes Prevention Program Outcomes Study (DPPOS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included DPPOS participants with ECG\u2010based heart rate variability (HRV) measured at the 10\u2010year examination. Resting heart rate (HR), standard deviation of all normal\u2010to\u2010normal intervals (SDNN), and root mean square of successive differences between normal\u2010to\u2010normal intervals (rMSSD) were measured. Multivariable linear regression models assessed the cross\u2010sectional associations of FPG, HbA\n                      <jats:sub>1C<\/jats:sub>\n                      , and fasting insulin and HOMA\u2010IR with cardiac autonomic function measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2266 participants (mean age 65\u2009years, 68.2% women, 53.4% White, 43.7% with prediabetes and 56.3% with diabetes at the time of evaluation), HbA\n                      <jats:sub>1C<\/jats:sub>\n                      , FPG, fasting insulin and HOMA IR were positively associated with high resting HR in men and women. HbA\n                      <jats:sub>1C<\/jats:sub>\n                      and FPG were inversely associated with rMSSD (\u03b2 [95% CI] per SD: \u22120.08 [\u22120.14, \u22120.03] and \u22120.08 [\u22120.13, \u22120.03]) and SDNN (\u22120.08 [\u22120.12, \u22120.03] and \u22120.07 [\u22120.11, \u22120.02]) among women, but not in men. Fasting insulin was inversely associated with rMSSD in the men (\u22120.09 [\u22120.18, 0.00]). HOMA\u2010IR was inversely associated with rMSSD in men (\u22120.11 [\u22120.20, \u22120.02] and women \u22120.07 [\u22120.12, \u22120.02]). HOMA\u2010IR was associated with SDNN only in women (\u22120.05 [\u22120.10, 0.00]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Markers of dysglycaemia are associated with worse ECG\u2010based autonomic dysfunction in adults with prediabetes and diabetes in the DPPOS, more so for some glycaemic markers and in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71111","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:06:53Z","timestamp":1788325613000},"page":"10743-10752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dysglycaemia and Autonomic Dysfunction: The Diabetes Prevention Program Outcomes Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-1617","authenticated-orcid":false,"given":"Justin B.","family":"Echouffo\u2010Tcheugui","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes &amp; Metabolism, Department of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Liu","sequence":"additional","affiliation":[{"name":"Biostatistics Center and Department of Biostatistics and Bioinformatics Milken Institute School of Public Health, George Washington University  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Epidemiological Cardiology Research Center, Department of Internal Medicine Section on Cardiovascular Medicine, Wake Forest School of Medicine  Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pi\u2010Sunyer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherita H.","family":"Golden","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes &amp; Metabolism, Department of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Dagogo\u2010Jack","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil H.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center  Torrance California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzoma","family":"Ibebuogu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Darwin","sequence":"additional","affiliation":[{"name":"Biostatistics Center and Department of Biostatistics and Bioinformatics Milken Institute School of Public Health, George Washington University  Rockville Maryland USA"},{"name":"Department of Medicine Ronald Reagan UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Knowler","sequence":"additional","affiliation":[{"name":"Biostatistics Center and Department of Biostatistics and Bioinformatics Milken Institute School of Public Health, George Washington University  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Temprosa","sequence":"additional","affiliation":[{"name":"Biostatistics Center and Department of Biostatistics and Bioinformatics Milken Institute School of Public Health, George Washington University  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the DPP Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10029"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2042"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002480"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1895"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.09.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.04.015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.7.5.447"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2175"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051344"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00920-6"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.3.668"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3534-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05316-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(98)00019-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000073062.29546.01"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2367"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.4.623"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0736(90)90085-G"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.45.030183.001125"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13635"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0125"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0364-y"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa055"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.4.513"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.5.624"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01496-z"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917080-00016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.06.034"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634949"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:20:54Z","timestamp":1792383654000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/dom.71111"],"URL":"https:\/\/doi.org\/10.1111\/dom.71111","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71111\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71111\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71111\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71111\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71111\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71111\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71111\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}