{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:56Z","timestamp":1792471136558,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014234","name":"Korean Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2C1005430"],"award-info":[{"award-number":["2022R1A2C1005430"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The early clinical impact of type 2 diabetes is not fully understood due to uncertainties surrounding the timing of disease onset. We assessed clinical outcomes in patients newly diagnosed with type 2 diabetes and without preexisting comorbidities, utilising the Korean National Health Insurance Service database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We identified patients (20\u201380\u2009years) newly diagnosed with type 2 diabetes without prior atherosclerotic cardiovascular or kidney disease (eGFR &lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , albuminuria, or relevant ICD codes). Age\u2010 and sex\u2010matched controls were selected (1:4). Primary outcomes included ischemic\/hemorrhagic stroke, myocardial infarction, heart failure, chronic kidney disease (CKD) progression to eGFR &lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , renal replacement therapy (RRT), and all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2\u2009164\u2009060 individuals, 432\u2009812 were newly diagnosed with type 2 diabetes. Participants were followed for a median of 5.1\u2009years (IQR 3.3\u20136.2\u2009years; maximum follow\u2010up 7.6\u2009years). After adjusting for covariates, the risks in the type 2 diabetes group remained significantly elevated compared to the controls: total composite outcome (hazard ratio, HR [95% confidence interval, CI]: 1.67 [1.64\u20131.70]), non\u2010renal composite outcome (1.57 [1.53\u20131.60]), renal composite outcome (1.86 [1.82\u20131.90]), and individual outcomes including ischemic stroke (1.73 [1.66\u20131.80]), hemorrhagic stroke (1.24 [1.14\u20131.35]), myocardial infarction (1.84 [1.73\u20131.95]), heart failure (2.17 [2.08\u20132.27]), CKD progression (1.47 [1.41\u20131.53]), RRT (4.17 [3.51\u20134.95]), and all\u2010cause mortality (1.14 [1.10\u20131.19]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients newly diagnosed with type 2 diabetes faced substantially increased risks of cardiovascular, renal complications, and all\u2010cause mortality, despite preserved baseline kidney function. Proactive risk assessments and preventive strategies are needed to mitigate the long\u2010term burden of diabetes\u2010related complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71116","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:16:41Z","timestamp":1784261801000},"page":"9069-9079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes for Newly Diagnosed Diabetes Patients in Korea: A National Health Insurance Data"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-0743","authenticated-orcid":false,"given":"Samel","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University Cheonan Hospital  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2018-2385","authenticated-orcid":false,"given":"Hyun Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-452X","authenticated-orcid":false,"given":"Hyung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Institute of Kidney Disease Research, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-3343","authenticated-orcid":false,"given":"Sun\u2010Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-0597","authenticated-orcid":false,"given":"Sang Youb","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2010Nephrology Inje University, Ilsan\u2010Paik Hospital  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01951-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800256"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0728-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.23.130"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.7.815"},{"issue":"2","key":"e_1_2_9_12_1","article-title":"Cohort Profile: The National Health Insurance Service\u2010National Sample Cohort (NHIS\u2010NSC), South Korea","volume":"46","author":"Lee J.","year":"2017","journal-title":"International Journal of Epidemiology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.5.395"},{"key":"e_1_2_9_14_1","volume-title":"National Health Screening Statistical Yearbook","year":"2023"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037885"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05977-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.015"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2024.111098"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1485"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2877"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070718"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.10.031"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4544-z"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12160"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.6.915"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515920"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.03.001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5599"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5087"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:52:09Z","timestamp":1792468329000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/dom.71116"],"URL":"https:\/\/doi.org\/10.1111\/dom.71116","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71116\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71116\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}