{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:52Z","timestamp":1792471132293,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373581"],"award-info":[{"award-number":["82373581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82495190"],"award-info":[{"award-number":["82495190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the associations between early\u2010pregnancy maternal overweight\/obesity metabolic phenotypes and foetal anthropometric measurements and assess mediation by gestational diabetes mellitus (GDM) and pregnancy\u2010induced hypertension (PIH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 7633 pregnant women from a Chinese prospective cohort. Participants in early pregnancy were classified as metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight\/obesity (MHO) and metabolically unhealthy overweight\/obesity (MUO). Generalised linear mixed models evaluated associations with repeated ultrasound measures for participants with at least one scan between 22 and 36\u2009weeks. Mediation analyses evaluated GDM and PIH effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to MHNW, both MHO and MUO were associated with higher estimated foetal weight (EFW) and abdominal circumference (AC)\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores mainly during 28\u201336\u2009weeks, as well as an elevated risk of foetal EFW and AC overgrowth. Furthermore, the MUO increased the risk of head circumference (HC) undergrowth (OR\u2009=\u20091.22, 95% CI: 1.00\u20131.48). Conversely, the MUNW was associated with lower foetal HC\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.05, 95% CI: \u22120.10 to 0.00). In addition, GDM mediated the association between MUNW and reduced foetal HC\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores at 28\u201332 and 33\u201336\u2009weeks, with mediation proportions of 11.2% and 16.1%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Early\u2010pregnancy maternal overweight\/obesity metabolic phenotypes are associated with foetal growth. MHO and MUO increase EFW and AC overgrowth risks, while MUO also raises HC undergrowth risk. Conversely, MUNW is associated with a reduced HC\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score, a pathway mediated by GDM. These findings highlight that the joint assessment of body mass index and metabolic health is vital for targeted maternal care.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71120","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:16:44Z","timestamp":1784261804000},"page":"9080-9090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Maternal Overweight\/Obesity Metabolic Phenotypes With Longitudinal Foetal Anthropometric Measurements"],"prefix":"10.1111","volume":"28","author":[{"given":"Xinxin","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical University  Nanjing China"},{"name":"Department of Maternal Child and Adolescent Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing 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