{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:43Z","timestamp":1792471123447,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231118"],"award-info":[{"award-number":["BK20231118"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is increasingly linked to cognitive decline, yet the hepatic factors associated with imaging\u2010derived neurovascular coupling (NVC) remain unclear. This study aimed to investigate whether liver stiffness or liver fat content was more closely associated with resting\u2010state CBF\u2010ReHo surrogate measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 130 participants including 98 MASLD patients and 32 age\u2010 and education\u2010matched healthy controls (HCs) underwent clinical assessment, neuropsychological testing, and multi\u2010modal MRI. Liver stiffness and fat content were quantified using MR elastography (MRE) and MRI\u2010proton density fat fraction (PDFF). Imaging\u2010derived NVC was assessed using global cerebral blood flow (CBF)\u2010regional homogeneity (ReHo) coupling and voxel\u2010wise CBF\/ReHo ratios, interpreted as resting\u2010state surrogates rather than direct stimulus\u2010evoked NVC. Multivariable regression and exploratory mediation analyses were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to HCs and patients with lower liver stiffness (MASLD_low), those with higher liver stiffness (MASLD_high) showed reduced global CBF\u2010ReHo coupling and altered CBF\/ReHo ratios, primarily localized to the bilateral superior temporal pole\/superior temporal gyrus (TPOsup). In multivariable regression, liver stiffness remained independently associated with TPOsup CBF\/ReHo ratios (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Exploratory mediation analysis showed a statistically significant indirect association between hepatocellular injury markers and TPOsup CBF\/ReHo ratios involving MRE\u2010derived liver stiffness (95% CI: 0.0795\u20130.2790).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within this cohort and the observed PDFF range, MRE\u2010derived liver stiffness was more closely associated with imaging\u2010derived NVC surrogate measures than liver fat content in MASLD. These findings are hypothesis\u2010generating and require validation in longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71125","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:34:09Z","timestamp":1784712849000},"page":"9239-9250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Closer Association of Liver Stiffness Than Liver Fat Content With Imaging\u2010Derived Neurovascular Coupling in a Metabolic Dysfunction\u2010Associated Steatotic Liver Disease Cohort"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhuoru","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"},{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-8645","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-1195","authenticated-orcid":false,"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"},{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30039-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000913"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00457-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2021.101801"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154770"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14161"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040673"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16362"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94234-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00320-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100992"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.11.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15549"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.08.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0322-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105079"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2201008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29302"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.231007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000670"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"487","article-title":"Guidelines for Diagnosis and Management of Metabolic Dysfunction\u2010Associated Fatty Liver Disease in Primary Care (2025)","volume":"14","author":"Ni W.","year":"2026","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90034-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15920"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-021-03324-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.025"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00005.2024"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332398"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109252"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7364649"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-019-00141-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.020"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01126-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00610-9"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201862119"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113970"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2203039119"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07349-5"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.09.003"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/13524585251330961"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:49:43Z","timestamp":1792468183000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/dom.71125"],"URL":"https:\/\/doi.org\/10.1111\/dom.71125","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71125\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71125\/v2\/review2","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}