{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:13Z","timestamp":1792384873734,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular\n                      <jats:italic>consequences<\/jats:italic>\n                      . This study explores the metabolic and renal effects of sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients with familial partial lipodystrophy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200957) or congenital generalised lipodystrophy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) (86% women) were initiated with SGLT2i in the French reference network PRISIS. We retrospectively collected clinical and biological data before initiation, after 6\u201318 months (short\u2010term, mean\u2009\u00b1\u2009SD 12.5\u2009\u00b1\u20096.4 months) and at the latest follow\u2010up on SGLT2i (long\u2010term, 29.0\u2009\u00b1\u200910.7 months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Body mass index decreased from 25 [22.9\u201328] (median [IQR]) to 24.4 [22.1\u201326.5] then 23.9 [22.1\u201326.4]\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and HbA1c from 7.8 [7.1\u20138.8] to 7.3 [6.7\u20137.7] and 7.3% [6.9\u20138] (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05, respectively). Systolic blood pressure (130 [120\u2013143.25] to 126 [120\u2013137]\u2009mmHg), ALT (33 [23.5\u201344] to 30 [26\u201340] IU\/L), GGT (44 [28.5\u201362.5] to 37 [27.85\u201345.5]\u2009IU\/L) and liver stiffness (6.8 [5.9\u201311.8] to 5.8 [5\u20136.9]\u2009kPa) declined significantly at short\u2010term (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, 0.02, 0.02 and &lt;\u20090.01, respectively). The dual\u2010energy X\u2010ray absorptiometry\u2010based fat mass percentage (23.6 [18\u201329.3] to 20.8 [17.8\u201325.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07) and truncal\u2010to\u2010lower limb fat ratio (1.36 [1.18\u20131.50] to 1.17 [0.98\u20131.41],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08) tended to decrease at short\u2010term. Urinary albumin\u2010to\u2010creatinine ratio, when elevated at baseline (&gt;\u20093\u2009mg\/mmol,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918 patients), decreased from 10.8 [6.3\u201324.9] to 8.0\u2009mg\/mmol [2.8\u201314.4] (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Treatment discontinuation (7%) was mainly due to vaginal mycoses. No serious adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a real\u2010life setting, SGLT2i therapy is associated with improvement in HbA1c, body weight, blood pressure, hepatic parameters and albuminuria in patients with genetic lipodystrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71126","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:24:36Z","timestamp":1787192676000},"page":"10318-10329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <scp>SGLT2<\/scp>\n                    Inhibitors in Patients With Genetic Lipodystrophy: A Real\u2010Life Experience From a National Reference 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