{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:47Z","timestamp":1792471127888,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) is the leading cause of mortality in individuals with diabetes. Diabetic kidney disease, closely related to CVD risk, is prevalent in up to 40% of this population. Emerging evidence suggests ceramide lipids as accurate biomarkers for CVD. We assessed the effect of four albuminuria\u2010lowering drugs on CVD\u2010related ceramides in diabetes by post hoc analysis of the ROTATE trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty six adults with type 1 (T1D) as well as 37 with type 2 diabetes (T2D) with a urine albumin\u2010creatinine ratio (UACR) of 30\u2013500\u2009mg\/g participated in a 4\u2010week 4\u2010time randomized crossover study with periods of telmisartan, empagliflozin, linagliptin and baricitinib treatment, each separated by a 4\u2010week washout period. Blood samples were collected at the beginning and end of each period and ceramide lipids (Cer16, Cer18, Cer20, Cer22, Cer24 and Cer24:1) were measured. The effect of each treatment was evaluated using linear mixed\u2010effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, individuals with T2D had greater levels of Cer22 and Cer24 compared to the individuals with T1D. Among the treatments, linagliptin was the only drug that demonstrated a reduction of Cer22, Cer24 and Cer24:1 from baseline by 22.6% (95% CI: \u221233.58; \u22129.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), 25.7% (95% CI: \u221238.94; \u22129.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and 19.6% (95% CI: \u221231.34; \u22125.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), respectively. No changes in the ceramides were observed for the other drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our exploratory findings suggest that certain albuminuria\u2010lowering drugs may affect ceramide levels as a secondary effect. However, further mechanistic investigations are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71130","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:18:16Z","timestamp":1785244696000},"page":"9346-9355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Albuminuria\u2010Lowering Treatments on Cardiovascular Predictive Ceramides in Diabetes: Post Hoc Analysis of the\n                    <scp>ROTATE<\/scp>\n                    Trials"],"prefix":"10.1111","volume":"28","author":[{"given":"Kristina","family":"Pigsborg","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Department of Clinical Medicine and Diabetes Novo Nordisk Foundation  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3401-8649","authenticated-orcid":false,"given":"Simon Maria","family":"Kienle","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Wretlind","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-6701","authenticated-orcid":false,"given":"Viktor","family":"Rotbain Curovic","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B\u00e6k","family":"Blond","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":false,"given":"Hiddo J. L.","family":"Heerspink","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-0352","authenticated-orcid":false,"given":"Tine Willum","family":"Hansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Persson","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Sulek","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"GLP\u20101 Center of Excellence, Research and Early Development Novo Nordisk A\/S  M\u00e5l\u00f8v Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-214X","authenticated-orcid":false,"given":"Cristina","family":"Legido\u2010Quigley","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-4294","authenticated-orcid":false,"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010018\u20100728\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.09.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319878371"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000377"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2017.10.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.4.421"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13825"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjopen\/oeae001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131838"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010015\u20100053\u2010y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100552"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08\u20101228"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2020.01.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.12.2614"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.570628"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.01.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2022.02.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2017.04.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010023\u201001922\u2010z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102021\u2010002395"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u20101699"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201052916\u2010w"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)64849\u20105"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00640"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160645"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010011\u20100088\u2010z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228004"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20101241.2009.02265.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101326.2010.01350.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00016"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055459"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14776"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010025\u201002611\u20102"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010025\u201002606\u2010z"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403347"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2023"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1245535"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx377"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010019\u20100994\u20107"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11072085"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116169"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07\u20100839"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010018\u20104590\u20106"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2016.12.003"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745\u2010006\u20105041\u20106"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201012\u20101424"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318264e380"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12369"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2021.105972"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13041"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30182\u20101"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20100323"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12936"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:50:27Z","timestamp":1792468227000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/dom.71130"],"URL":"https:\/\/doi.org\/10.1111\/dom.71130","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71130\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71130\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"2026-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}