{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:41:04Z","timestamp":1792482064775,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aims<\/jats:title>\n To assess the added value of absolute anthropometric targets alongside percentage weight loss in the clinical management of obesity.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n The phase 3a, 68\u2010week REDEFINE 1 trial randomised adults without diabetes with BMI \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n , or\u2009\u2265\u200927\u2009kg\/m\n 2<\/jats:sup>\n with \u2265\u20091 obesity\u2010related complication, to once\u2010weekly CagriSema 2.4\u2009mg\/2.4\u2009mg, semaglutide 2.4\u2009mg, cagrilintide 2.4\u2009mg, or placebo, plus lifestyle intervention. This secondary,\n post hoc<\/jats:italic>\n analysis assessed the proportions of participants achieving BMI <\u200927\u2009kg\/m\n 2<\/jats:sup>\n and\/or WHtR <\u20090.53 targets, and percentage weight loss by anthropometric target. The association between the proportion of participants maintaining or achieving normalisation of four cardiometabolic outcomes: normoglycemia (glycated haemoglobin <\u20095.7% and fasting plasma glucose <\u20095.6\u2009mmol\/L); blood pressure (<\u2009130\/80\u2009mmHg); triglycerides (<\u20091.7\u2009mmol\/L); lipids (high\u2010density lipoprotein cholesterol \u2265\u20091.3\u2009mmol\/L [female] or \u2265\u20091.0\u2009mmol\/L [male]) and reaching anthropometric targets or change in body weight (%) was also assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The proportion of participants achieving both BMI <\u200927\u2009kg\/m\n 2<\/jats:sup>\n and WHtR <\u20090.53 targets at week 68 was 30.3%, 19.1%, 9.0%, and 3.3% in participants who received CagriSema, semaglutide, cagrilintide, or placebo respectively. Both BMI and WHtR performed similarly as indicators for all four cardiometabolic outcomes. At more stringent cut\u2010off values, anthropometric targets were better measures than percentage weight loss.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The proportion of participants achieving anthropometric targets was greater with CagriSema Versus other treatments. These findings support further validation of BMI and WHtR anthropometric treatment targets and indicate a potential for indicating amelioration of clinical outcomes in obesity and a greater emphasis on target\u2010based treatment strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.71134","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:53:09Z","timestamp":1785120789000},"page":"9317-9325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of\n CagriSema<\/scp>\n for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary,\n \n Post hoc<\/i>\n <\/scp>\n Analysis of\n REDEFINE<\/scp>\n 1"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-8980","authenticated-orcid":false,"given":"Luca","family":"Busetto","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Osorto","family":"Contreras","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Hovden","family":"Christensen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Timothy","family":"Garvey","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah B.","family":"Horn","sequence":"additional","affiliation":[{"name":"Center for Obesity Medicine and Metabolic Performance University of Texas McGovern Medical School Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"McGowan","sequence":"additional","affiliation":[{"name":"Guy's and St. Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire Prener","family":"Miller","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Schnecke","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-5445","authenticated-orcid":false,"given":"Carel W.","family":"le Roux","sequence":"additional","affiliation":[{"name":"Diabetes Complications Research Centre Conway Institute, University College Dublin Dublin Ireland"},{"name":"Diabetes Research Centre Ulster University Coleraine UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab848"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization \u201cObesity: Preventing and Managing the Global Epidemic. 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