{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:14:22Z","timestamp":1788412462882,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficiency of the AID system with Control\u2010IQ technology and carbohydrate counting (CHC)\u2013based premeal bolus to control postprandial glucose (PPG) after mixed meals with different macronutrient compositions in adolescents with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In this prospective crossover study, 25 adolescents with T1D using an automated insulin delivery (AID\u2014Tandem Tslim X2 with Control\u2010IQ) consumed three iso\u2010caloric meals (745\u2009kcal) on separate days: a standard meal (56.5% carbohydrate), a high\u2010fat (HF) meal (45.9% fat), and a high\u2010protein (HP) meal (24.4% protein). A CHC\u2010based bolus was administered 15\u2009min before each meal. Continuous glucose monitoring metrics and AID insulin delivery were assessed over 6\u2009h. The primary outcome was 6\u2010h time in range (TIR, 70\u2013180\u2009mg\/dL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six\u2010hour TIR was significantly lower after HF (65.2%) and HP meals (49.9%) compared with the standard meal (84.3%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). Postprandial glucose exposure (AUC above 140 and 180\u2009mg\/dL) was significantly higher after HF and HP meals at both 3 and 6\u2009h. The AID system delivered significantly more insulin than the pre\u2010programmed basal for HF (+26% at 6\u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and HP meals (+55% at 6\u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), without increasing hypoglycemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite a substantial autonomous increase in insulin delivery, AID systems using Control\u2010IQ technology and a standard CHC\u2010based pre\u2010meal bolus have not achieved adequate postprandial glycemic control after HF and HP meals. Proactively timed, meal\u2010specific insulin strategies are required to improve postprandial outcomes after nutritionally complex meals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71135","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:56:44Z","timestamp":1784602604000},"page":"9178-9187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postprandial Glycemic Control With Automated Insulin Delivery With Control\u2010\n                    <scp>IQ<\/scp>\n                    Technology: The Impact of Meal Composition"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-8807","authenticated-orcid":false,"given":"Marco","family":"Marigliano","sequence":"first","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-8317","authenticated-orcid":false,"given":"Claudia","family":"Piona","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Morotti","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Macedoni","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parto","family":"Kharazizadeh","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mancioppi","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Tomasselli","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology University of Verona  Verona 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