{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:27Z","timestamp":1791434967601,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists can produce rapid weight loss, but this loss is frequently accompanied by disproportionate loss of lean mass, particularly during the early phase of GLP\u20101\u2010treatment. Physical activity (PA), particularly resistance training, is the most effective behavioural strategy for enhancing fat reduction while preserving lean mass. Our primary aim was to evaluate whether a 12\u2010week virtual GLP\u20101 lifestyle companion programme that includes PA coaching was associated with increased weight and fat loss coupled with preservation of muscle mass among adults with obesity who initiated GLP\u20101 therapy for weight loss \u2264\u20098\u2009weeks prior to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this quasi\u2010experimental trial, 245 adults (151 intervention and 94 control) received either a virtual GLP\u20101 lifestyle companion programme with personalised, strength\u2010focused PA coaching or usual care. Body composition was captured using home bioelectrical impedance analysis scales. Primary outcomes were 12\u2010week between\u2010group differences in change in weight, percent body fat and percent muscle mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants in the GLP\u20101 lifestyle companion programme lost an adjusted mean of 6.0% of their baseline body weight versus 3.3% in the control group (between\u2010group difference 2.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compared with controls, they also experienced a larger decline in body fat percentage (\u22123.3% vs. \u22121.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), a greater increase in muscle mass percentage (+0.6% vs. +0.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and greater improvements in psychosocial and behavioural outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Personalised, virtually delivered PA programming may meaningfully improve the quantity and quality of weight loss during GLP\u20101 therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71152","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:54:16Z","timestamp":1788306856000},"page":"10636-10647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality Plus Quantity: Evaluation of a Virtual\n                    <scp>GLP<\/scp>\n                    \u20101 Programme With Physical Activity Support to Promote Healthy Body Composition Change During\n                    <scp>GLP<\/scp>\n                    \u20101 Weight Loss"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-1708","authenticated-orcid":false,"given":"Lisa A.","family":"Stanton","sequence":"first","affiliation":[{"name":"Omada Health Inc.  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanean B.","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Omada Health Inc.  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Omada Health Inc.  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"McGuill","sequence":"additional","affiliation":[{"name":"Omada Health Inc.  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Norwood","sequence":"additional","affiliation":[{"name":"Omada Health Inc.  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Linke","sequence":"additional","affiliation":[{"name":"Omada Health Inc.  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