{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:52Z","timestamp":1792471132223,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real\u2010world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes in urinary albumin\u2010to\u2010creatinine ratio (UACR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>MEDFINE\u2010RWD was a multicentre, retrospective study across eight Spanish centres, enrolling patients initiating finerenone (June 2024\u2013December 2025). The primary endpoint was a \u2265\u200930% reduction in UACR. Multivariable logistic regression identified response predictors. Secondary outcomes included safety (hyperkalaemia \u2265\u20095.5\u2009mmol\/L, major kidney [MAKE] and cardiovascular events [MACE]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 844 participants (median age 72\u2009years; median follow\u2010up 184\u2009days; 76.8% male; baseline eGFR 49\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ; UACR 285\u2009mg\/g; 77.8% were at high\/very high KDIGO risk), finerenone was associated with a 34.5% median UACR reduction at 6\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), despite intensive SGLT2 inhibitors (88.4%) and GLP\u20101 receptor agonists (35.7%) use. The primary endpoint was achieved by 52.7%, consistently across background renoprotection or baseline KDIGO risk strata. Predictors of response were age\u2009\u2265\u200970 (aOR 2.12), baseline UACR &gt;\u2009245\u2009mg\/g (aOR 1.94), and BMI &gt;\u200927\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (aOR 1.84), while insulin use was associated with lower response odds. Treatment persistence was 89.5%, with low incidences of hyperkalaemia (4.8%), MAKE (0.9%), and MACE (1.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In real\u2010world practice, finerenone was associated with a substantial reduction in albuminuria. Finerenone demonstrated high persistence and a favourable safety profile, irrespective of baseline renoprotective regimens or KDIGO risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71160","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:29:45Z","timestamp":1785468585000},"page":"9461-9472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (\n                    <scp>MEDFINE<\/scp>\n                    \u2010\n                    <scp>RWD<\/scp>\n                    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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Tom\u00e1s\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Endocrinology Unit University Hospital of Torrec\u00e1rdenas  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"V\u00e1zquez\u2010San Miguel","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Germans Trias i Pujol University Hospital  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Soria\u2010Utrilla","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Biomedical Research Institute of Malaga (IBIMA) Faculty of Medicine, University of Malaga  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada Mar\u00eda","family":"Rold\u00e1n\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition General University Hospital Dr. Balmis of Alicante, Institute of Health and Biomedical Research of Alicante (ISABIAL)  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-9383","authenticated-orcid":false,"given":"Maya","family":"S\u00e1nchez\u2010Baya","sequence":"additional","affiliation":[{"name":"Department of Nephrology Germans Trias i Pujol University Hospital  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jersy","family":"C\u00e1rdenas\u2010Salas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid 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