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Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an atherogenic lipid profile that accelerates atherosclerosis and vascular dysfunction. While statins remain the cornerstone of lipid\u2010lowering therapy, their cardiovascular benefits decline in advanced CKD. Combination therapy with ezetimibe and newer agents, including PCSK9 inhibitors and bempedoic acid, has shown further cardiovascular risk reduction in CKD. Emerging therapies targeting alternative pathways may address residual lipid abnormalities not corrected by traditional treatments but require longer\u2010term outcome data in people with DM and CKD. As the prevalence of both conditions rises, applying multifaceted lipid\u2010lowering strategies may yield the greatest reduction in cardiovascular events and improve survival among this vulnerable population.<\/jats:p>","DOI":"10.1111\/dom.71180","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:48:17Z","timestamp":1787633297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6571-8032","authenticated-orcid":false,"given":"Ann S.","family":"Forrest","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Virginia Commonwealth University  Richmond Virginia 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