{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:24Z","timestamp":1792384884109,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23AA2003"],"award-info":[{"award-number":["23AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The association between glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101RA) use and the development of bowel obstruction\/ileus remains unclear, and evidence for specific bowel obstruction\/ileus subtypes remains limited. We examined the association between GLP\u20101RA use and the incidence of bowel obstruction\/ileus subtypes across different subgroups of individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the commercially available Japanese administrative claims DeSC database, we identified individuals aged \u2265\u200918\u2009years with type 2 diabetes who newly initiated either GLP\u20101RAs or sodium\u2010glucose cotransporter 2 inhibitors (SGLT2is) between April 2016 and February 2024. An active\u2010comparator new\u2010user design was adopted, designating GLP\u20101RA users as the exposure group and SGLT2i users as the control group. The primary outcome was bowel obstruction\/ileus requiring tube decompression or surgery within 1\u2009year. Secondary outcomes included specified small bowel obstruction, small bowel obstruction requiring surgery, paralytic ileus and colonic volvulus. Inverse probability weighting with propensity scores was used to adjust for confounding. Adjusted cumulative incidence was estimated using Kaplan\u2013Meier methods; hazard ratios were estimated using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 298\u2009124 eligible individuals, 25\u2009779 and 272\u2009345 were classified into the GLP\u20101RA and SGLT2i groups, respectively. The adjusted 1\u2010year incidence proportion of the primary outcome did not significantly differ between groups (0.14% vs. 0.17%; difference \u22120.03%, 95% confidence interval (CI), \u22120.10% to 0.04%; hazard ratio 0.80, 95% CI, 0.52\u20131.24). No significant between\u2010group differences were observed for the secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101RA initiation in individuals with type 2 diabetes was not associated with an increased risk of bowel obstruction\/ileus compared with SGLT2i initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71189","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T02:16:35Z","timestamp":1786328195000},"page":"9941-9954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bowel Obstruction\/Ileus Associated With the Use of Glucagon\u2010Like Peptide\u20101 Receptor Agonists: A Nationwide Database Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-8628","authenticated-orcid":false,"given":"Yuichiro","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-3388","authenticated-orcid":false,"given":"Akira","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Prevention of Diabetes and Lifestyle\u2010Related Diseases, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Cancer Institute Hospital of Japanese Foundation for Cancer Research  Koto\u2010ku Tokyo Japan"},{"name":"Department of Healthcare Quality Assessment, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00203-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-076410"},{"key":"e_1_2_10_4_1","unstructured":"Pharmaceuticals and Medical Devices Agency \u201cPharmaceuticals and Medical Devices Safety Information. No. 291 June 2012 \u201daccessed June 30 2025 https:\/\/www.pmda.go.jp\/files\/000153459.pdf."},{"key":"e_1_2_10_5_1","unstructured":"European Medicines Agency \u201cPharmacovigilance Risk Assessment Committee (PRAC): Minutes of the Meeting\u20147\u201310 January 2013 \u201daccessed June 30 2025 https:\/\/www.ema.europa.eu\/en\/documents\/minutes\/minutes\u2010prac\u2010meeting\u20107\u201010\u2010january\u20102013_en.pdf."},{"key":"e_1_2_10_6_1","unstructured":"U.S. Food and Drug Administration \u201cApril\u2013June 2022|Potential Signals of Serious Risks\/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS) \u201daccessed June 30 2025 https:\/\/www.fda.gov\/drugs\/fdas\u2010adverse\u2010event\u2010reporting\u2010system\u2010faers\/april\u2010june\u20102022\u2010potential\u2010signals\u2010serious\u2010risksnew\u2010safety\u2010information\u2010identified\u2010fda\u2010adverse\u2010event."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2430"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.08.034"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-025-02525-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16642"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.06.003"},{"issue":"4","key":"e_1_2_10_12_1","first-page":"291","article-title":"Adhesive Small Bowel Obstruction: Epidemiology, Biology and Prevention","volume":"50","author":"Attard J.\u2010A. 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