{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:24Z","timestamp":1792384884001,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore whether fatty liver index (FLI) stratification is associated with differential glycemic responses to sodium\u2010glucose co\u2010transporter\u20102 (SGLT2) versus dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors as second\u2010line therapy in type 2 diabetes without established atherosclerotic cardiovascular disease (ASCVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this exploratory post hoc analysis of a previous 52\u2010week randomised trial of ipragliflozin versus sitagliptin added to metformin in Japanese patients with type 2 diabetes, 91 patients were stratified by median FLI into low (&lt;\u200951;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944) and high (\u2265\u200951;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947) groups. The outcome was the 52\u2010week change in glycated haemoglobin A1c (HbA1c). The treatment\u2010by\u2010FLI interaction was tested by baseline\u2010HbA1c\u2010adjusted analysis of covariance; FLI was also modelled continuously and parallel analyses used body mass index (BMI) and alanine aminotransferase (ALT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The baseline\u2010HbA1c\u2010adjusted treatment\u2010by\u2010FLI interaction was significant at 52\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013): ipragliflozin was associated with a greater HbA1c reduction than sitagliptin in the high FLI group (\u22120.41%, 95% confidence interval \u22120.77, \u22120.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023), with no significant difference in the low FLI group (+0.24%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.194). The interaction was also significant with FLI modelled continuously (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and in mixed\u2010model and multiple\u2010imputation sensitivity analyses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010 and 0.003). BMI and ALT showed similar significant interactions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028 and 0.032), favouring ipragliflozin in the high\u2010value subgroup. FLI provided the clearest signal but was not the only effect modifier.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FLI\u2010based stratification was associated with differential glycemic responses to ipragliflozin versus sitagliptin. These findings are hypothesis\u2010generating, given the small, complete\u2010case sample and the sample\u2010derived cut\u2010off. Prospective studies are warranted before FLI can inform antidiabetic drug selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71211","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:38:33Z","timestamp":1786952313000},"page":"10110-10121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatty Liver Index and Differential Glycemic Responses to Ipragliflozin Versus Sitagliptin Over 52\u2009Weeks: An Exploratory Post Hoc Analysis of the Niigata Ipragliflozin and Sitagliptin With Metformin (N\u2010\n                    <scp>ISM<\/scp>\n                    ) Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-2793","authenticated-orcid":false,"given":"Masaru","family":"Kitazawa","sequence":"first","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Niigata University Faculty of Medicine  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