{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:24Z","timestamp":1792384884057,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We assessed the age\u2010specific associations between moderate\u2010to\u2010vigorous physical activity (MVPA) and incident type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We included UK Biobank participants with valid accelerometry data without diabetes mellitus at baseline (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200987\u2009975; 62.7\u2009years [IQR, 55.6\u201367.9]; 57% women). We examined whether age, sex and baseline metabolic disease status modified the associations of MVPA volume (lower versus higher) and, in exploratory analyses, MVPA timing (later\u2010day versus earlier\u2010day) with incident type 2 diabetes. Age\u2010specific relative and absolute associations were assessed across 5\u2010year age bins using hazard ratios (HRs) and incidence rate differences (IRDs), and additionally stratified by sex and baseline metabolic disease status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Associations of MVPA volume with type 2 diabetes were most consistently modified by age, baseline prediabetes (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values for interaction &lt;\u20090.05), with stronger associations observed among participants younger than the median population age (&lt;\u200962.7\u2009years, HR\u2009=\u20092.44 [95% CI: 2.05\u20132.90] versus HR\u2009=\u20091.65 [95% CI: 1.47\u20131.86]) and participants without prediabetes. Across 5\u2010year age groups, HRs declined with age, whereas IRDs increased in the overall population. No clear effect modification was observed for the association between MVPA timing and type 2 diabetes risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The relative association between higher MVPA volume and lower type 2 diabetes risk attenuated with age and was weaker among individuals with prediabetes, whereas absolute risk reductions were larger among older and metabolically higher\u2010risk individuals. These findings support considering both relative and absolute measures when targeting MVPA interventions for type 2 diabetes prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71214","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:57:38Z","timestamp":1786676258000},"page":"10099-10109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Specific Associations of Moderate\u2010to\u2010Vigorous Physical Activity With Relative and Absolute Risk of Type 2 Diabetes in\n                    <scp>UK<\/scp>\n                    Biobank Participants"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0710-4905","authenticated-orcid":false,"given":"Qiuyu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-809X","authenticated-orcid":false,"given":"Raymond","family":"Noordam","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Caecilia Institute for Population Health and Data Sciences Leiden University Medical Center  Leiden the Netherlands"},{"name":"Health Campus the Hague\/Public Health and Primary Care Leiden University Medical Center  the Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-9637","authenticated-orcid":false,"given":"Denghui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-5328","authenticated-orcid":false,"given":"Gali","family":"Albalak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Psychiatry Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-7394","authenticated-orcid":false,"given":"Ko","family":"Willems van Dijk","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-7748","authenticated-orcid":false,"given":"Diana","family":"van Heemst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1842"},{"issue":"1","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjsem-2016-000143","article-title":"Update on the Effects of Physical Activity on Insulin Sensitivity in Humans","volume":"2","author":"Bird S. 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