{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:20Z","timestamp":1792384880621,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370819"],"award-info":[{"award-number":["82370819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82088102"],"award-info":[{"award-number":["82088102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506700"],"award-info":[{"award-number":["2023YFC2506700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012515","name":"Cyrus Tang Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether participants with different cardiometabolic renal health profiles would derive comparable cognitive benefits from intensive blood pressure (BP)\u2010lowering treatment remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) derived a cardiometabolic renal health profile based on baseline levels of fasting plasma glucose, non\u2010high\u2010density lipoprotein cholesterol, estimated glomerular filtration rate, urine albumin\u2010to\u2010creatinine ratio and history of subclinical and clinical cardiovascular disease. Participants were categorised into tertiles (favourable, intermediate and poor) based on the distribution of the risk\u2010weighted profile. Cognitive outcomes included probable dementia, mild cognitive impairment (MCI) and a composite of the two.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 8162 participants (mean age 67.8\u2009years; 35.2% women) with complete baseline profile data were included. In exploratory tertile\u2010based analyses, intensive BP\u2010lowering treatment was associated with a lower risk of MCI among participants with favourable profiles (adjusted HR 0.64, 95% CI 0.48\u20130.86), with the largest absolute risk difference observed in this group (adjusted ARD, \u22123.05%; 95% CI, \u22124.85% to \u22121.24%) and a significant interaction on the ARD scale (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.039). No interaction was observed for the other cognitive outcomes or adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intensive BP\u2010lowering treatment tended to be associated with greater absolute risk reductions for MCI among participants with favourable cardiometabolic renal health profiles. These findings should be considered exploratory and require validation in future studies.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT01206062.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71217","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:45:19Z","timestamp":1786592719000},"page":"10058-10069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic Renal Health Profile, Intensive Blood Pressure\u2010Lowering Treatment and Cognitive Dysfunction: A Post Hoc Analysis of the\n                    <scp>SPRINT<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Siyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Clinical Research Center for Endocrine and Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-7594","authenticated-orcid":false,"given":"Kan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin 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Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Clinical Research Center for Endocrine and Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Clinical Research Center for Endocrine and Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health 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