{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:34Z","timestamp":1791434974099,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sodium\u2013glucose cotransporter 2 inhibitors (SGLT2i) are commonly withheld during hospitalisation because of concerns about diabetic ketoacidosis. We examined whether hospitalisation was associated with discontinuation of SGLT2i and compared patterns with another anti\u2010hyperglycaemic medicine without similar inpatient safety concerns: dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective new\u2010user cohort study using linked, population\u2010level data for adult residents of New South Wales, Australia. Adults aged \u2265\u200940\u2009years initiating SGLT2i or DPP\u20104i (separate cohorts) between 2016 and 2020 were followed until death, mid\u20102021, or treatment discontinuation (gap of \u2265\u200990\u2009days without a dispensing of the index medicine). We used Cox proportional hazards models to estimate the association between hospitalisation and discontinuation, adjusting for demographic and clinical characteristics. We treated the \u2018hospitalisation period\u2019 (the inpatient stay plus the 90\u2009days following discharge) as a time\u2010dependent exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among people initiating SGLT2i (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106\u2009098), the median age was 63\u2009years and 61% were male. Overall, 35.1% were hospitalised during follow\u2010up, and discontinuation was substantially more frequent during the hospitalisation period (56.4 per 100 person\u2010years) compared with other follow\u2010up times (37.6 per 100 person\u2010years). This association remained significant after adjustment (HR: 1.83; 95% CI: 1.79\u20131.87). Similar patterns were observed among DPP\u20104i treated people (HR: 1.55; 95% CI: 1.51\u20131.58).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hospitalisation is a strong risk factor for discontinuation of SGLT2i and DPP\u20104i therapy. Strategies to support re\u2010initiation of SGLT2i during transitions from hospital to community care are needed to prevent harm and maximise cardiorenal protective effects of these medicines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71219","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:12Z","timestamp":1787017872000},"page":"10210-10217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hospitalisation Is a Strong Risk Factor for Discontinuation of Sodium\u2010Glucose Cotransporter 2 Inhibitors for Type 2 Diabetes"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0538-2661","authenticated-orcid":false,"given":"Tamara Y.","family":"Milder","sequence":"first","affiliation":[{"name":"Medicines Intelligence Research Program, School of Population Health University of New South Wales  Sydney Australia"},{"name":"School of Clinical Medicine, UNSW Medicine &amp; Health, St Vincent's Healthcare Clinical Campus University of New South Wales  Sydney Australia"},{"name":"St Vincent's &amp; Mater Clinical School, School of Medicine The University of Notre Dame  Sydney Australia"},{"name":"Department of Endocrinology St Vincent's Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Medicines Intelligence Research Program, School of Population Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7959-1548","authenticated-orcid":false,"given":"Hans Kristian","family":"Raket","sequence":"additional","affiliation":[{"name":"Medicines Intelligence Research Program, School of Population Health University of New South Wales  Sydney Australia"},{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Copenhagen Phase IV Unit, Department of Clinical Pharmacology and Center for Clinical Research and Prevention University Hospital of Copenhagen\u2014Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry R.","family":"Greenfield","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, UNSW Medicine &amp; Health, St Vincent's Healthcare Clinical Campus University of New South Wales  Sydney Australia"},{"name":"Department of Endocrinology St Vincent's Hospital  Sydney Australia"},{"name":"Victor Chang Cardiac Research Institute  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-6937","authenticated-orcid":false,"given":"Richard O.","family":"Day","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, UNSW Medicine &amp; Health, St Vincent's Healthcare Clinical Campus University of New South Wales  Sydney Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-9191","authenticated-orcid":false,"given":"Jialing","family":"Lin","sequence":"additional","affiliation":[{"name":"International Centre for Future Health Systems University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"de Oliveira Costa","sequence":"additional","affiliation":[{"name":"Medicines Intelligence Research Program, School of Population Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Stocker","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, UNSW Medicine &amp; Health, St Vincent's Healthcare Clinical Campus University of New South Wales  Sydney Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Australia"},{"name":"Department of Pharmacy Westmead Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Australia"},{"name":"Department of Renal Medicine Royal North Shore Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-8380","authenticated-orcid":false,"given":"Brendon","family":"Neuen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Australia"},{"name":"Department of Renal Medicine Royal North Shore Hospital  Sydney Australia"},{"name":"The George Institute for Global Health, University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-7535","authenticated-orcid":false,"given":"Min","family":"Jun","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Ludington","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St Vincent's Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie\u2010Anne","family":"Pearson","sequence":"additional","affiliation":[{"name":"Medicines Intelligence Research Program, School of Population Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-7272","authenticated-orcid":false,"given":"Michael O.","family":"Falster","sequence":"additional","affiliation":[{"name":"Medicines Intelligence Research Program, School of Population Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001184"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065748"},{"key":"e_1_2_9_4_1","volume-title":"Use of SGLT2\u2010Inhibitors for Type 2 Diabetes in Acute Inpatient Care: Clinical Practice Guide","author":"NSW Agency for Clinical Innovation","year":"2023"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16061"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100617"},{"key":"e_1_2_9_7_1","volume-title":"Medication Management at Transitions of Care Stewardship Framework","author":"Australian Commission on Safety and Quality in Health Care","year":"2025"},{"key":"e_1_2_9_8_1","unstructured":"The Commonwealth Fund \u201cInternational Health Care System Profiles: Australia \u201d2026 https:\/\/www.commonwealthfund.org\/international\u2010health\u2010policy\u2010center\/countries\/australia."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5887"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-021122"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000477"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15241"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-025-06439-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.24926\/iip.v15i4.6432"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"S267","article-title":"16. Diabetes Care in the Hospital: Standards of Care in Diabetes\u20102023","volume":"46","author":"American Diabetes Association","year":"2023","journal-title":"Diabetes Care"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1129"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc26-S016"},{"key":"e_1_2_9_18_1","volume-title":"Perioperative Management of SGLT2 Inhibitors and GLP\u20101 Receptor Agonists: Practice Tool","author":"Council of Australian Therapeutic Advisory Groups","year":"2024"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcae068"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.20834"},{"issue":"4","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","journal-title":"Kidney International"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2026.01.020"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:01:21Z","timestamp":1791432081000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/dom.71219"],"URL":"https:\/\/doi.org\/10.1111\/dom.71219","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71219\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71219\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71219\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71219\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71219\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}