{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:29Z","timestamp":1791434969876,"version":"4.3.3"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Managing postprandial glycaemic variability is crucial for preventing metabolic diseases. Although the effects of a vegetable\u2010first meal sequence on blood glucose levels have been well documented, there is limited research on consecutive, repeated meal sequencing for healthy young women. This study investigated the effects of 3\u2010day repeated interventions on glycaemic profiles in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this randomized crossover trial, 33 healthy Korean women consumed isocaloric test meals under four conditions: (1) VPC (vegetables\u2010protein\u2010carbohydrates meal sequence) with 35\u2009min meal limit; (2) CPV (carbohydrates\u2010protein\u2010vegetables meal sequence) with 35\u2009min meal limit; (3) TGR (all together without sequence) with 35\u2009min meal limit; (4) NTL (no meal intake time limit). Glycaemic profiles and variability were examined by continuous glucose monitoring over 3\u2009h after each meal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to CPV, TGR and NTL, the VPC reduced the glucose incremental area under the curve for 0\u20131\u2009h and 0\u20132\u2009h and mean glucose for 0\u20131\u2009h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). VPC also resulted in lower peak glucose and delayed time\u2010to\u2010peak compared to CPV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Time in range was the highest for VPC and VPC significantly reduced the mean amplitude of glycaemic excursion (MAGE) compared to all other sequences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VPC improves postprandial glycaemic control, demonstrating consistent benefits across different meal constraints, including unrestricted eating (NTL). Optimizing meal sequencing represents a potential strategy for managing metabolic health and preventing early\u2010onset type 2 diabetes in young women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71227","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:08:10Z","timestamp":1787018890000},"page":"10218-10226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vegetable\u2010First Meal Sequence Suppresses Postprandial Glycaemic Excursions and Variability in Young Women With High\u2010Risk Phenotype for Early\u2010Onset Type 2 Diabetes: A 4\u2010Arm Randomized Crossover Trial With Continuous Glucose Monitoring"],"prefix":"10.1111","volume":"28","author":[{"given":"Minji","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Graduate School of Clinical Biohealth Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"},{"name":"Graduate Program in System Health Science &amp; Engineering Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eujean","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"},{"name":"Graduate Program in System Health Science &amp; Engineering Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ijae","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"},{"name":"Graduate Program in System Health Science &amp; Engineering Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehyun","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonseo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Vogue","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Health Convergence Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Graduate School of Clinical Biohealth Ewha Womans University  Seoul Republic of Korea"},{"name":"Department of Nutritional Science and Food Management Ewha Womans University  Seoul Republic of Korea"},{"name":"Graduate Program in System Health Science &amp; Engineering Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-8306","authenticated-orcid":false,"given":"Jieun","family":"Oh","sequence":"additional","affiliation":[{"name":"College of Science and Industry Convergence Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(25)00299\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30186\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2024.0826"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201080790\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092217"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071652"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.51"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2024.112602"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2007.02362.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12098"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(06)69703\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.9.2574"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.881"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151018381"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051279"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000034509.14906.ae"},{"key":"e_1_2_10_19_1","volume-title":"Dr. Atkins' New Diet Revolution","author":"Atkins R.","year":"1998"},{"key":"e_1_2_10_20_1","volume-title":"The Zone: A Dietary Road Map","author":"Sears B.","year":"1995"},{"key":"e_1_2_10_21_1","volume-title":"Every Day Cooking With Dean Ornish","author":"Ornish D.","year":"1997"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2015.9.6.658"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2019.107450"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn.2014.23.2.01"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20102244"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102017\u2010000440"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13503"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S468628"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.04.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u2010S002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15\u20100429"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15143269"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1281978"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17040658"},{"key":"e_1_2_10_35_1","volume-title":"2024 Korean Time Use Survey","author":"Statistics Korea","year":"2024"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7083106"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.13\u201067"},{"key":"e_1_2_10_38_1","volume-title":"Dietary Reference Intakes for Koreans","author":"Ministry of Health and Welfare, The Korean Nutrition Society","year":"2025"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20101600"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092767"},{"issue":"6","key":"e_1_2_10_41_1","first-page":"565","article-title":"Influencia de la velocidad de la ingesti\u00f3n de la comida en la glucemia postprandial [Influence of the velocity of meal ingestion on postprandial glycemia]","volume":"132","author":"Frati\u2010Munari A. C.","year":"1996","journal-title":"Gaceta M\u00e9dica de M\u00e9xico"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.56"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15051174"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010015\u20103841\u2010z"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.202"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.06.005"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2539S"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000574n"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5917085"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u20101956"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155640"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11070983"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.0114"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00051.2009"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2026.156570"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:01:45Z","timestamp":1791432105000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/dom.71227"],"URL":"https:\/\/doi.org\/10.1111\/dom.71227","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71227\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71227\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}