{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:24Z","timestamp":1792384884626,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014592","name":"Insulet Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Analyse the cost\u2010effectiveness of the Omnipod 5 automated insulin delivery system versus multiple daily injections (MDI) with continuous glucose monitoring for type 1 diabetes among adults in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cost\u2010effectiveness was analysed with the IQVIA Core Diabetes Model (version 10.0) taking the perspective of the payer in Sweden including healthcare system and combined healthcare system and societal costs. Treatment effects were derived from the RADIANT randomised controlled trial and acute complication rates from Biester et\u00a0al. 2021. Treatment\u2010specific health utilities were sourced from a Time Trade\u2010Off (TTO) elicitation study. Incremental costs, life expectancy, quality\u2010adjusted life\u2010years (QALY) and incremental cost\u2013utility ratios (ICURs) were calculated using a 50\u2010year time horizon for the base case and sensitivity analysis tested changes in parameters including treatment effects, baseline HbA1c and time horizons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Omnipod 5 was found to be cost\u2010effective in the base case and sensitivity analyses, with ICURs below the willingness\u2010to\u2010pay threshold of 500\u2009000 SEK per QALY. In the base case Omnipod 5 was found to have lower rates of diabetes\u2010related complications and provide 3.82 in additional QALY. Higher therapy costs with Omnipod 5 were offset by savings in the cost of complications and savings in costs associated with absenteeism. Considering direct costs only the ICUR was 201\u2009161 SEK per QALY. Considering combined costs it was 179\u2009247 SEK per QALY.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Omnipod 5 was found to offer superior value compared with MDI, showing cost\u2010effectiveness for adults with type 1 diabetes in Sweden with better patient outcomes and fewer complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71231","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:00:57Z","timestamp":1786953657000},"page":"10142-10152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Omnipod 5 Delivers Superior Economic Value Compared to Multiple Daily Injections: A Cost\u2010Effectiveness Analysis in Adults With\n                    <scp>T1D<\/scp>\n                    From a Payer Perspective in Sweden"],"prefix":"10.1111","volume":"28","author":[{"given":"Johan","family":"Jendle","sequence":"first","affiliation":[{"name":"Institute of Medical Sciences, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hopley","sequence":"additional","affiliation":[{"name":"Insulet  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Narang","sequence":"additional","affiliation":[{"name":"IQVIA  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7220-5361","authenticated-orcid":false,"given":"Raffaele","family":"Scarica","sequence":"additional","affiliation":[{"name":"Insulet  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Hellerstedt","sequence":"additional","affiliation":[{"name":"Nordic Infucare AB  Bromma Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Littlewood","sequence":"additional","affiliation":[{"name":"Insulet  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112277"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)60591\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010022\u201001938\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20102112"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16\u20101990"},{"key":"e_1_2_11_7_1","unstructured":"NDR \u201cSweden National Diabetes Registry 2024\u201325 \u201d 2025 https:\/\/rcvgr.shinyapps.io\/ndrapp\/."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101850"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf034"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010023\u201001394\u20105"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20100172"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20102359"},{"key":"e_1_2_11_13_1","first-page":"1","volume-title":"Pediatric Diabetes","author":"Hood K. 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