{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:35Z","timestamp":1791434975071,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160139"],"award-info":[{"award-number":["82160139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We prospectively investigated the association between the European Association for the Study of Obesity (EASO) modified obesity definition and the incidence of type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We analysed data from the NAfld in the Gifu Area Longitudinal Analysis (NAGALA) cohort, an ongoing community\u2010based health screening program in Japan. Obesity was defined using both traditional body mass index (BMI) categories and the new EASO definition (BMI 23\u201327.5\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      plus waist\u2010to\u2010height ratio \u2265\u20090.5 and at least one obesity\u2010related comorbidity). T2DM was identified during follow\u2010up based on haemoglobin A1c (HbA1c)\u2009\u2265\u20096.5%, fasting plasma glucose \u2265\u20097.0\u2009mmol\/L, or self\u2010reported physician diagnosis of diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 13\u2009825 adults without diabetes at baseline. According to the new EASO definition, 10.3% of the study population (1424 individuals, representing 31.3% of those originally classified as overweight by BMI) were reclassified as having obesity. Compared with individuals with normal weight, those with EASO\u2010defined overweight showed an increased risk of T2DM [hazard ratio (HR): 1.48, 95% confidence interval (CI): 1.10\u20132.00], while those with EASO\u2010defined new obesity demonstrated a significantly elevated risk (HR: 5.06, 95% CI: 3.86\u20136.62). After multivariable adjustment for age, sex, smoking status, alcohol consumption, physical activity, and HbA1c, the adjusted HR for EASO\u2010defined new obesity remained significantly elevated at 2.68 (95% CI: 2.03\u20133.54). When compared with normal\u2010weight individuals without comorbidities, EASO\u2010defined new obesity was associated with a higher T2DM risk (HR: 4.14, 95% CI: 2.77\u20136.19) than normal\u2010weight individuals with comorbidities (HR: 1.95, 95% CI: 1.30\u20132.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The new EASO framework may improve the identification of individuals at high risk of incident type 2 diabetes mellitus compared with traditional BMI criteria alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71232","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:57:41Z","timestamp":1786953461000},"page":"10153-10162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>EASO<\/scp>\n                    's New Obesity Framework and Incident Type 2 Diabetes: A Prospective Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Zejin","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolism The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-3662","authenticated-orcid":false,"given":"Yuanyuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi 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Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-3003","authenticated-orcid":false,"given":"Jixiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5278-6432","authenticated-orcid":false,"given":"Jiancheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang University  Nanchang Jiangxi 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