{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:22Z","timestamp":1792384882389,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify low\u2010 and high\u2010risk intervals for major adverse cardiovascular events (MACE) and all\u2010cause mortality according to lipid ratios in adults with Type 2 diabetes mellitus (T2DM), stratified by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We used primary care electronic health records from the Spanish National Health Service including 303\u2009199 adults with T2DM followed for a mean of 5.7\u2009years (1.7 million person\u2010years). Lipid indices were triglycerides\/HDL cholesterol (TG\/HDL\u2010C), total cholesterol\/HDL cholesterol (TC\/HDL\u2010C), non\u2013HDL cholesterol\/HDL cholesterol, LDL cholesterol\/HDL cholesterol and the triglyceride\u2013glucose (TyG) index. The outcome was a composite of all\u2010cause mortality or hospitalisation for cerebrovascular or ischemic heart disease. Sex\u2010specific Weibull models adjusted for clinical covariates were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>U\u2010shaped associations were observed between lipid ratios and outcomes. Increased risk was associated with higher ratios in both sexes, with slightly lower risk thresholds in women, while very low values were also linked to excess risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Extremes of lipid ratios were associated with higher cardiovascular risk, suggesting that moderate ranges may be protective. These easily obtainable markers may improve risk stratification and personalised prevention in T2DM care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71236","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:53Z","timestamp":1787019053000},"page":"10236-10247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Lipid Ratios With Cardiovascular Outcomes in Type 2 Diabetes: A Population Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-1633","authenticated-orcid":false,"given":"Enrique","family":"Carretero\u2010Anibarro","sequence":"first","affiliation":[{"name":"Health Center Jos\u00e9 Gallego Arroba Andalusian Health Service  Puente Genil Cordoba Spain"},{"name":"Clinical Medicine Department, School of Medicine Miguel Hern\u00e1ndez University of Elche (UMH)  San Juan de Alicante Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-7531","authenticated-orcid":false,"given":"Jose Antonio","family":"Quesada","sequence":"additional","affiliation":[{"name":"Clinical Medicine Department, School of Medicine Miguel Hern\u00e1ndez University of Elche (UMH)  San Juan de Alicante Alicante Spain"},{"name":"Primary Care Research Center Miguel Hernandez University of Elche (UMH)  San Juan de Alicante Alicante Spain"},{"name":"Cardiovascular Reseach Group GRINCAVA Miguel Hern\u00e1ndez University of Elche (UMH)  San Juan de Alicante Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-5115","authenticated-orcid":false,"given":"Manuel A.","family":"Ruiz\u2010Quintero","sequence":"additional","affiliation":[{"name":"Clinical Medicine Department, School of Medicine Miguel Hern\u00e1ndez University of Elche (UMH)  San Juan de Alicante Alicante 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