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Effects on the liver fat in adults with fatty liver disease are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this randomized double\u2010masked controlled trial was to compare the effects of a dietary soybean oil (SO) which is high in LA vs. palm oil (PO) which is composed of a mixture of saturated, mono\u2010 and polyunsaturated fats, on changes of liver fat level in adults with MAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adults with MAFLD were recruited to complete a double\u2010masked, randomized controlled trial consisting of a 2\u2010week run\u2010in period followed by a 16\u2010week dietary intervention. Study foods contained either SO or PO to deliver 30\u2009g oils per day. At week 0 and week 16, liver fat and visceral adipose tissue were measured by\n                      <jats:sup>1<\/jats:sup>\n                      H\u2010magnetic resonance spectroscopy imaging and fasting blood was collected for secondary biochemical markers of cardiometabolic disease risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010five adults with MAFLD (mean age ~53 y, BMI 36\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) completed the study. Overall, there was a significant difference in the change of liver fat between SO and PO groups; however, after adjusting for baseline liver fat the diet group differences were no longer significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14). The direct effect of diet group on the change of liver fat was not mediated by weight change (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11). For within group change, liver fat tended to decrease in SO group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11) and tended to increase in PO group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no significant difference for the effect of PO over SO on liver fat change when controlling for baseline liver fat or weight change. Larger trials testing dietary strategies that reduce liver fat in adults with MAFLD in the context of weight change are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>\n                      The WELL study is registered on ClinicalTrials.gov (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05199948?cond=NAFLD&amp;lat=40.0060889&amp;lng=-83.0282624&amp;locStr=The Ohio State University, West Lane Avenue, Columbus, OH&amp;distance=50&amp;page=2&amp;rank=12\">NCT05199948<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  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