{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:19Z","timestamp":1792384879785,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>People with diabetes and chronic kidney disease (CKD) may be at increased risk of iatrogenic hypoglycaemia. We compared rates of sensor\u2010detected (SDH) and person\u2010reported hypoglycaemia (PRH) in people with insulin\u2010treated Type 2 diabetes (T2D) with and without CKD in the Hypo\u2010METRICS study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Method<\/jats:title>\n                    <jats:p>\n                      Insulin\u2010treated T2D patients with &gt;\u20091 hypoglycaemic episode within the last 3\u2009months wore a blinded continuous glucose monitor (CGM) and recorded PRH on the bespoke Hypo\u2010METRICS app for 10\u2009weeks. SDH was defined as per consensus guidelines. The participants were grouped based on estimated glomerular filtration rate (eGFR), that is CKD 1 (eGFR\u2009\u2265\u200990\u2009mL\/min;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009117), CKD 2 (eGFR 60\u201389\u2009mL\/min;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009140), and CKD 3 (eGFR 30\u201359\u2009mL\/min;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956). We used descriptive statistics, Kruskal\u2010Wallis rank sum tests, and a negative binomial models to control for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 313 participants with T2DM were included. Median age increased with declining eGFR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Median (IQR) events per week for SDH\u2009&lt;\u20093.9\u2009mmol\/L were 1.72 (0.66\u20133.43) in CKD 1, 2.12 (0.85\u20134.55) in CKD 2, and 2.22 (1.09\u20134.57) in CKD 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12). For SDH\u2009&lt;\u20093.0\u2009mmol\/L, these rates were 0.20 (0.00\u20130.50), 0.21 (0.10\u20130.61), and 0.20 (0.00\u20130.71), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.88). PRH events had medians of 1.05 (0.40\u20132.12), 1.31 (0.61\u20132.42), and 1.28 (0.68\u20132.25) for CKD 1, CKD 2, and CKD 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.24).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In people with insulin\u2010treated T2DM and CKD stages 2 or 3, the rates of SDH and PRH do not significantly differ from those in people without CKD.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTRials.gov<\/jats:ext-link>\n                      : NCT04304963\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71247","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:23:14Z","timestamp":1788254594000},"page":"10664-10669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Person\u2010Reported and Continuous Glucose Monitoring (\n                    <scp>CGM<\/scp>\n                    ) Recorded Hypoglycaemia in People With Insulin\u2010Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo\u2010\n                    <scp>METRICS<\/scp>\n                    Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-4407","authenticated-orcid":false,"given":"Julie M. B.","family":"Br\u00f8sen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nephrology Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"},{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Malmsi\u00f8","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nephrology Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Divilly","sequence":"additional","affiliation":[{"name":"Department of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Department of Endocrinology St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberte","family":"Martine\u2010Edith","sequence":"additional","affiliation":[{"name":"Department of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-1621","authenticated-orcid":false,"given":"Natalie","family":"Zaremba","sequence":"additional","affiliation":[{"name":"Department of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Department of Medical Psychology Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-7820","authenticated-orcid":false,"given":"Namam","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-1981","authenticated-orcid":false,"given":"Rory J.","family":"McCrimmon","sequence":"additional","affiliation":[{"name":"Systems Medicine, School of Medicine University of Dundee  Dundee Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-9565","authenticated-orcid":false,"given":"Simon","family":"Heller","sequence":"additional","affiliation":[{"name":"University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-8987","authenticated-orcid":false,"given":"Mark","family":"Evans","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Science and Department of Medicine University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan","family":"de Galan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Centre  Nijmegen the Netherlands"},{"name":"CARIM School for Cardiovascular Diseases Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-4233","authenticated-orcid":false,"given":"Julia K.","family":"Mader","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Montpellier University Hospital  Montpellier France"},{"name":"Institute of Functional Genomics University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan A.","family":"Vaag","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Diabetes, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Diabetes Research Centre University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-4880","authenticated-orcid":false,"given":"Ulrik","family":"Pedersen\u2010Bjergaard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nephrology Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the HypoRESOLVE Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.18"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.537"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2008.02496.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.B4909"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1003795"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00800209"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/ENDREV\/BNAA017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231174040"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/DME.14892"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20102332"},{"issue":"5","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2022.06.008","article-title":"KDIGO 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