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Sympathetic denervation increased both sensory neuropeptide levels and sensory innervation at 7\u2009days, which may explain the minimal whole\u2010body impacts, since sensory nerves can contribute to many of the same metabolic processes as sympathetic nerves in adipose. In acute studies, intra\u2010ing\u2010scWAT norepinephrine delivery increased calcitonin gene related peptide (CGRP) levels in the depot, while CGRP administration reduced norepinephrine levels, underscoring previous reports of nerve cross talk at the tissue level. Multi\u2010omics profiling of sympathetically denervated ing\u2010scWAT revealed selective remodelling of lipid signalling pathways, including accumulation of polyunsaturated fatty acid\u2010derived oxylipins from the cytochrome P450 pathway, alongside perturbations in tricarboxylic acid cycle metabolism. These changes were distinct from CL316,243 treatment. Single\u2010nuclei transcriptomics identified cell\u2010type\u2010specific re\u2010programming, including altered oxidative phosphorylation and lipid metabolic pathways in adipocytes and increased immune cell representation with sympathetic denervation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Together, these data demonstrate that sympathetic denervation of scWAT induces coordinated metabolic, lipidomic, and transcriptional changes in the tissue as well as alterations to energy balance. Nerve crosstalk and potential compensation by sensory axons may help explain the findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71251","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:23:31Z","timestamp":1787711011000},"page":"10459-10474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 6\u2010\n                    <scp>OHDA<\/scp>\n                    \u2010Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue"],"prefix":"10.1111","volume":"28","author":[{"given":"Gilian","family":"Gunsch","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery The Ohio State University College of Medicine and Wexner Medical Center  Columbus Ohio 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