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This study investigated the association between CDB burden and glycemic outcomes during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 246 pregnant women were recruited at 18\u201324\u2009weeks' gestation. Four CDBs were assessed using dietary records and questionnaires: eating jetlag, predominant night\u2010eating, social jetlag, and electronic media use before bedtime. Outcomes included oral\u2010glucose\u2010tolerance\u2010test (OGTT) and insulin parameters (24\u201328\u2009weeks' gestation) and continuous\u2010glucose\u2010monitoring (CGM) metrics (18\u201324\u2009weeks' gestation). Skewed outcomes were log\u2010transformed, and associations with the number of CDBs were examined using multivariable regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with women without CDBs, those with two CDBs had higher fasting insulin [geometric mean ratio 1.23 (95% CI 1.02, 1.48)] and updated\u2010homeostasis\u2010model\u2010assessment\u2010of\u2010insulin\u2010resistance (HOMA2\u2010IR) [1.23 (1.02, 1.47)]. Women with three or four CDBs had significantly higher fasting glucose [1.09 (1.04, 1.15)], 1\u2010h glucose [1.17 (1.03, 1.33)], glucose area\u2010under\u2010the\u2010curve [1.14 (1.03, 1.26)], and lower updated\u2010homeostasis\u2010model\u2010assessment\u2010of\u2010\u03b2\u2010cell\u2010function (HOMA2\u2010%B) [0.76 (0.62, 0.93)]. Furthermore, fetal sex modified the associations between CDBs and CGM\u2010derived glycemic control measures, including mean glucose, glucose management indicator (GMI), and J\u2010index (all\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      &lt;\u20090.1). In stratified analyses, a higher cumulative CDB measure was significantly associated with higher glycemic control measures among women carrying female foetuses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher CDB burden was associated with less favourable glycemic profiles and lower HOMA2\u2010%B during pregnancy. These findings support investigating circadian\u2010aligned lifestyle strategies to improve maternal metabolic health.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT03803345.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71264","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:29:05Z","timestamp":1787711345000},"page":"10486-10497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Circadian\u2010Disruptive Behaviours With Plasma Glycemic Parameters and Continuous Glucose Monitoring Measures Among Pregnant 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