{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:18Z","timestamp":1792384878123,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whole blood viscosity (WBV) is associated with impaired microvascular circulation and cardiovascular risk in patients with Type 2 diabetes mellitus (T2DM) and peripheral artery disease (PAD). This study investigated the efficacy and safety of sarpogrelate compared with aspirin on WBV in patients with T2DM and PAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomised, open\u2010label clinical trial enrolled adults with T2DM and PAD. A total of 66 participants were randomised to aspirin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) or sarpogrelate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) for 24\u2009weeks. The primary endpoint was change in diastolic WBV at a shear rate of 1\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      from baseline to week 24. Secondary endpoints included tissue oxygen delivery index, pain visual analogue scale (VAS) and cold sensation scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 24\u2009weeks, diastolic WBV did not decrease significantly in both groups (sarpogrelate group: 31.91\u2009\u00b1\u20097.83 to 30.76\u2009\u00b1\u20097.08, mean change, \u22121.15\u2009\u00b1\u20099.25;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.509; aspirin group: 33.32\u2009\u00b1\u20098.86 to 32.12\u2009\u00b1\u20099.60, mean change, \u22121.20\u2009\u00b1\u20098.36;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.432). VAS scores improved significantly in both groups (mean change, \u22129.09\u2009\u00b1\u200918.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007 for sarpogrelate; \u22126.13\u2009\u00b1\u200916.47;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047 for aspirin), with no between\u2010group difference. Cold sensation scores improved only in the sarpogrelate group (mean change, \u22120.21\u2009\u00b1\u20090.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033 vs. \u22120.23\u2009\u00b1\u20090.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.147 for aspirin group), with no between\u2010group difference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with T2DM and PAD, sarpogrelate did not significantly improve WBV compared with aspirin. VAS scores and cold sensation improved significantly within the sarpogrelate group with no between\u2010group difference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71265","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:42:46Z","timestamp":1787632966000},"page":"10449-10458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Sarpogrelate Versus Aspirin on Whole Blood Viscosity in Patients With Type 2 Diabetes and Peripheral Artery Disease"],"prefix":"10.1111","volume":"28","author":[{"given":"Fatima","family":"Nari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-5014","authenticated-orcid":false,"given":"Jooyeop","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-1671","authenticated-orcid":false,"given":"Soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01118-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.09.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2015.39.4.283"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944714553226"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repce.2019.04.001"},{"issue":"6","key":"e_1_2_9_7_1","first-page":"902","article-title":"Blood Rheology and Hemodynamics","volume":"50","author":"Baskurt O. 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