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Adults with T2D and BMI\u2009&lt;\u200927\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      newly initiating non\u2010tirzepatide GLP\u20101 RAs were compared with new users of dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i), sodium\u2013glucose cotransporter\u20102 inhibitors (SGLT2i) or usual care. Comparisons used separate 1:1 propensity score matching. The primary outcome was all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 7389, 8969 and 8610 GLP\u20101 RA users were matched to DPP\u20104i, SGLT2i and usual care. Versus DPP\u20104i, GLP\u20101 RA was associated with lower all\u2010cause mortality (hazard ratio [HR] 0.61; 95% confidence interval [CI] 0.52\u20130.71), major adverse cardiovascular events (MACE; HR 0.83; 95% CI 0.71\u20130.98) and coded heart failure (HR 0.71; 95% CI 0.60\u20130.85). Versus SGLT2i, MACE (HR 0.81; 95% CI 0.69\u20130.95) and coded heart failure (HR 0.56; 95% CI 0.47\u20130.65) were lower, but all\u2010cause mortality was not (HR 0.89; 95% CI 0.76\u20131.05). Gastroparesis was more frequent versus DPP\u20104i.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In people with T2D and BMI\u2009&lt;\u200927\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , GLP\u20101 RA use was associated with lower coded heart failure risk across all three comparisons, the most consistent finding. The lower all\u2010cause mortality association versus DPP\u20104i and usual care, absent versus SGLT2i, should be interpreted cautiously as likely reflecting residual confounding rather than a benefit of this magnitude.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71266","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:51:53Z","timestamp":1787712713000},"page":"10498-10512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiorenal Mortality and Safety Outcomes of\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists in Type 2 Diabetes With\n                    <scp>BMI<\/scp>\n                    Below 27\u2009kg\/m\n                    <sup>2<\/sup>\n                    : A Target Trial Emulation"],"prefix":"10.1111","volume":"28","author":[{"given":"Shao\u2010Chia","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Genetics and Endocrinology, Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-1685","authenticated-orcid":false,"given":"Yu\u2010Nan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Genetics and Endocrinology, Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Genetics and Endocrinology, Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Genetics and Endocrinology, Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Meyerowitz\u2010Katz","sequence":"additional","affiliation":[{"name":"School of Health and Society University of Wollongong  Wollongong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-7927","authenticated-orcid":false,"given":"Shun\u2010Fa","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Medical 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