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Eicosanoids are bioactive lipids that govern the upstream initiation of pro\u2010 and anti\u2010inflammatory activity. We sought to investigate the association of eicosanoids with obesity, adiposity, and cardiometabolic traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional analysis of the Multi\u2010Ethnic Study of Atherosclerosis (MESA) study with external validation in two community\u2010based cohorts: Framingham Heart Study and Atherosclerosis Risk in Communities Study. We measured 811 eicosanoids using a directed, non\u2010targeted mass spectrometry\u2010based platform and examined their associations with BMI and eight related adiposity and cardiometabolic traits using multivariable\u2010adjusted linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 5101 MESA participants (mean age 63\u2009years, 53% women), we found 255 eicosanoids and related metabolites associated with BMI (FDR\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.01 for all). Among these, 82 showed consistent associations across all three cohorts, including 18 metabolites with known identities: 9 were associated with lower BMI including docosahexaenoic acid derivative 19,20\u2010DiHDPA, arachidonic acid derivatives (20\u2010carboxy\u2010arachidonic acid, 5,6\u2010diHETrE, 14,15\u2010diHETrE, 15\u2010HpETE), and eicosapentaenoic acid derivative 5\u2010HpEPE. By contrast, 9 metabolites associated with higher BMI including hydroxyoctadecenoic acid (HOME), 11\u2010hydroxy\u20109\u2010octadecenoic acid (11\u2010HOME), and adrenic acid. Many BMI\u2010associated metabolites overlapped with other adipose traits including 240 (94%) with waist circumference and 93 (36%) with visceral adipose tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified 82 BMI\u2010associated eicosanoids, including docosanoids and arachidonic acid derivatives associated with lower BMI, while octadecanoids and adrenic acid derivatives were associated with higher BMI. Our findings highlight the role of bioactive lipids and specific pro\u2010 and anti\u2010inflammatory pathways that may underlie adverse cardiometabolic consequences of obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71269","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:12:31Z","timestamp":1788253951000},"page":"10696-10708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Eicosanoids and Eicosanoid\u2010Related Metabolites With Obesity and Cardiometabolic Traits"],"prefix":"10.1111","volume":"28","author":[{"given":"Mandana","family":"Chitsazan","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhi K.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Division of 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