{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:26Z","timestamp":1791434966168,"version":"4.3.3"},"reference-count":81,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003524","name":"Ministry of Business, Innovation and Employment","doi-asserted-by":"publisher","award":["3710040"],"award-info":[{"award-number":["3710040"]}],"id":[{"id":"10.13039\/501100003524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low energy diets (LEDs) are effective for body weight (BW) loss and improvement of type 2 diabetes (T2D) risk biomarkers. Emerging evidence suggests that whole fruit feijoa powder, rich in polyphenols and abscisic acid, may further support T2D prevention. The FERDINAND study investigated whether daily consumption of a whole fruit feijoa powder enhanced LED\u2010driven improvements in fasting plasma glucose (FPG), BW, and other metabolic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      At in\u2010clinic screening, 97 participants were enrolled into the trial and randomised to receive 1150\u2009mg\/day of whole fruit feijoa powder (Fx,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948) or Placebo treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949) for 6\u2009months. All participants underwent 2\u2009months of LED\u2010induced weight loss, followed by 4\u2009months of dietary advice for weight loss maintenance. BW, FPG, and secondary outcomes including blood pressure (BP) were assessed at baseline (M0) and the end of months 2 (M2), 4 (M4), and 6 (M6). Data were analysed using linear mixed\u2010effects models as intention\u2010to\u2010treat (ITT) with imputation for missing not\u2010at\u2010random data points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BW decreased in both treatment groups during the 2\u2010month LED, with a gradual upward trajectory over the subsequent 4\u2009months (time\n                      <jats:sub>0\u20106m<\/jats:sub>\n                      :\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was no difference in BW between Fx and Placebo over the 6\u2010month intervention (treatment\u00d7time\n                      <jats:sub>0\u20106m<\/jats:sub>\n                      :\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74). FPG followed the weight loss trajectory in both treatment groups (time\n                      <jats:sub>0\u20106m<\/jats:sub>\n                      :\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but with no between\u2010group interaction over 6\u2009months (treatment\u00d7time\n                      <jats:sub>0\u20106m<\/jats:sub>\n                      :\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200997). Systolic BP (SBP), but not diastolic BP, declined over the 6\u2009months between treatments (treatment\u00d7time\n                      <jats:sub>0\u20106m<\/jats:sub>\n                      :\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) in all participants, with SBP in Fx lower than Placebo at M4 and M6 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, both).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults with overweight (predominantly obesity) and prediabetes, Fx supplementation may enhance blood pressure improvement achieved through BW loss. The polyphenolic matrix of whole fruit feijoa, which contains a high proportion of catechins, may have contributed to vascular benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71270","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:13:51Z","timestamp":1788254031000},"page":"10709-10724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Whole Fruit Feijoa Powder for Type 2 Diabetes Risk Prevention: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6125-1481","authenticated-orcid":false,"given":"I. A.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Human Nutrition Unit, School of Biological Sciences, Faculty of Science University of Auckland  Auckland New Zealand"},{"name":"High Value Nutrition National Science Challenge  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-9925","authenticated-orcid":false,"given":"I. R.","family":"Sequeira\u2010Bisson","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Biological Sciences, Faculty of Science University of Auckland  Auckland New Zealand"},{"name":"High Value Nutrition National Science Challenge  Auckland New Zealand"},{"name":"Riddet Institute, Massey University  Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-9276","authenticated-orcid":false,"given":"J. J.","family":"Lim","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Biological Sciences, Faculty of Science University of Auckland  Auckland New Zealand"},{"name":"High Value Nutrition National Science Challenge  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-0151","authenticated-orcid":false,"given":"L. D.","family":"Plank","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-2423","authenticated-orcid":false,"given":"R.","family":"Murphy","sequence":"additional","affiliation":[{"name":"High Value Nutrition National Science Challenge  Auckland New Zealand"},{"name":"Department of Medicine University of Auckland  Auckland New Zealand"},{"name":"Auckland Diabetes Centre Health New Zealand, Te Whatu Ora  Auckland New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-8378","authenticated-orcid":false,"given":"S. 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