{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:21Z","timestamp":1792384881185,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine whether insulin resistance (IR), assessed by cumulative triglyceride\u2013glucose (TyG)\u2010derived indices and change patterns, stratifies incident cardiovascular disease (CVD) risk after glycaemic transition in adults with prediabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Data were obtained from 1468 participants with prediabetes in the China Health and Retirement Longitudinal Study. Glycaemic transition and TyG\u2010derived indices were assessed from Wave 1 to Wave 3. Indices included TyG, TyG\u2010ABSI (a body shape index), TyG\u2010BRI (body roundness index), TyG\u2010CVAI (Chinese visceral adiposity index) and TyG\u2010WWI (weight\u2010adjusted waist index). Cumulative indices summarised measurements across Waves 1 and 3 and exploratory\n                      <jats:italic>k<\/jats:italic>\n                      \u2010means clustering identified broad two\u2010wave exposure patterns. Incident CVD was assessed from Waves 3 to 5. Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median 5.0\u2010year follow\u2010up, 294 CVD events occurred. Compared with persistent prediabetes, reversion to normoglycaemia was not associated with lower CVD risk (HR 0.97, 95% CI 0.72\u20131.31), whereas progression to diabetes was associated with higher risk (HR 1.53, 95% CI 1.14\u20132.07). In joint analyses, reversion with low cumulative indices was not associated with increased CVD risk, whereas reversion with high indices was significantly associated with elevated risk for most indices (HRs 1.55\u20132.05). Among participants who reverted to normoglycaemia, high cumulative TyG\u2010derived indices were significantly associated with higher CVD risk (adjusted HRs 1.89\u20132.52; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Change\u2010pattern analyses were concordant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Glycaemic transition status did not fully stratify subsequent CVD risk. Cumulative TyG\u2010related measures further stratified CVD risk across glycaemic transition groups, including among participants who reverted to normoglycaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71280","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:38:02Z","timestamp":1787711882000},"page":"10526-10539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insulin Resistance\u2013Adiposity Burden and Incident Cardiovascular Disease Across Glycaemic Transitions in Prediabetes: Risk Stratification After Reversion to Normoglycaemia"],"prefix":"10.1111","volume":"28","author":[{"given":"Huimin","family":"Cai","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangge","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Qiu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Ye","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-7407","authenticated-orcid":false,"given":"Enmin","family":"Xie","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-2376"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2297"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019045"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.100958"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60525-X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.8774"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0656"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4895-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.4989"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00295-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.9.975"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164115610057"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00612-X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0288"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12303"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4678526"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-026-03191-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.02.014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02972-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02902-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02873-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-025-02499-y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38214"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-026-03152-w"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0034"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13350"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01017-4"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvac001"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2017.10.001"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00141"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01541-5"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0762-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-02115-9"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02572-w"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02278-z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00247-1"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2023.11.006"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd11110350"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:19:23Z","timestamp":1792383563000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/dom.71280"],"URL":"https:\/\/doi.org\/10.1111\/dom.71280","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71280\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71280\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"2026-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}