{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:27Z","timestamp":1791434967070,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501081"],"award-info":[{"award-number":["82501081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12\u2010months open\u2010source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included people with T1D who had used AAPS continuously for 12\u2009months. Glycemic outcomes were assessed at 3, 6, and 12\u2009months post\u2010initiation by age stratification (2\u20137, 8\u201312, 13\u201318, 19\u201330, 31\u201345, and &gt;\u200945\u2009years). Factors associated with achieving composite target of time in range of 70\u2013180\u2009mg\/dL[TIR]\u2009&gt;\u200970% and time below range of 70\u2009mg\/dL [TBR70] &lt;\u20094% at 12\u2009months were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 190 individuals were enrolled, with median age of 26.1 (11.9, 36.7) years and T1D duration of 2.1 (0.2, 8.4) years. Mean TIR remained high and stable during 12\u2009months (79.9%\u2009\u00b1\u200911.8%, 77.8%\u2009\u00b1\u200913.9%, and 77.2%\u2009\u00b1\u200913.5% at 3, 6, and 12\u2009months), with TBR70 of 3.8 (1.9, 6.1)%, 3.3 (1.6, 5.8)% and 3.6 (2.0, 6.6)% respectively. However, outcomes varied by age. At 12\u2009months, TIR was 72.8%\u2009\u00b1\u200915.5% in 13\u201318\u2009years group, with TBR70 of 4.2 [2.7, 6.3]%, while &gt;\u200945\u2009years group had TIR of 78.9%\u2009\u00b1\u200911.8% and relatively less hypoglycemia (TBR70, 2.5 [1.2, 5.9]%). In exploratory analyses, higher target achievement rate of the composite target was associated with longer time in automation in adults (OR 1.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and higher meal announcement frequency in paediatrics under 18\u2009years (OR 1.35;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Open\u2010source AAPS achieved sustained glycemic improvement across age groups in T1D people. Age\u2010related differences in influencing factors highlight the need for age\u2010tailored strategies to optimise long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71281","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:45:28Z","timestamp":1787885128000},"page":"10625-10635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Glycemic Outcomes of Open\u2010Source Automated Insulin Delivery During 12\u2009Months Among People With Type 1 Diabetes Across Age Groups"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-9091","authenticated-orcid":false,"given":"Qiongyan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Diabetology  Guangzhou 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