{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:22Z","timestamp":1792384882000,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate changes in glycaemic control following semaglutide discontinuation in adults with Type 1 diabetes and obesity who completed the ADJUST\u2010T1D randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Continuous glucose monitoring (CGM) data were collected during a 12\u2010week extension phase after the ADJUST\u2010T1D trial. Analyses included participants previously randomised to semaglutide who discontinued treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) and participants previously randomised to placebo who did not receive a glucagon\u2010like peptide\u20101 receptor agonist during follow\u2010up (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922). Changes in CGM\u2010derived metrics from Week 26 to the extension phase were compared using Wilcoxon rank\u2010sum tests with Benjamini\u2013Hochberg adjustment. Analysis of covariance (ANCOVA) adjusting for Week 26 values was performed as a sensitivity analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with placebo, participants who discontinued semaglutide experienced a greater decline in time in range (70\u2013180\u2009mg\/dL) (median change \u22123.6% vs. 1.5%; adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044). Semaglutide discontinuation was also associated with greater increases in glucose standard deviation (6.0 vs. 1.2\u2009mg\/dL; adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and coefficient of variation (3.1% vs. 1.1%; adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044), indicating worsening glycaemic variability. Time above range (&gt;\u2009180\u2009mg\/dL) increased numerically but did not remain significant after adjustment (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.064). No significant between\u2010group differences were observed in hypoglycaemia\u2010related CGM metrics. ANCOVA analyses showed consistent findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults with Type 1 diabetes and obesity, semaglutide discontinuation was associated with a greater decline in time in range and increased glycaemic variability compared with placebo over 12\u2009weeks. These findings suggest that glycaemic benefits achieved during treatment may not be fully sustained following withdrawal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71287","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:42:50Z","timestamp":1788234170000},"page":"10736-10742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycaemic Changes After Semaglutide Discontinuation in Adults With Type 1 Diabetes Using Automated Insulin Delivery: Analysis of the\n                    <scp>ADJUST<\/scp>\n                    \u2010\n                    <scp>T1D<\/scp>\n                    Extension Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3138-1964","authenticated-orcid":false,"given":"Eslam","family":"Montaser","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-0142","authenticated-orcid":false,"given":"Kanchan","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida","family":"Kruger","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5179","authenticated-orcid":false,"given":"Halis Kaan","family":"Akturk","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-5404","authenticated-orcid":false,"given":"Andrew","family":"Ahmann","sequence":"additional","affiliation":[{"name":"OHSU Harold Schnitzer Diabetes Health Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9337-3740","authenticated-orcid":false,"given":"Janet K.","family":"Snell\u2010Bergeon","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3827-7107","authenticated-orcid":false,"given":"Viral N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Diabetes and Metabolic Diseases Indiana University School 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2500173"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u20102249"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15325"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103680"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14725"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70185"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010025\u201009950\u20104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2026.103796"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7797"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3224"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24331"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200618"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101444"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13552"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100631"}],"container-title":["Diabetes, Obesity and 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