{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:12:13Z","timestamp":1788426733738,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","award":["2204\u201005183"],"award-info":[{"award-number":["2204\u201005183"]}],"id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Oxytocin has been proposed to exert glucose\u2010stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin during a graded glucose infusion on glucose\u2010regulating hormones and markers of bone turnover in healthy men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In a randomised, placebo\u2010controlled, double\u2010blind, crossover study, healthy men received intravenous infusions of oxytocin (0.1 or 0.2\u2009IU\/min, or placebo [saline], respectively) on three separate days during a three\u2010hour intravenous graded glucose infusion with increases every 30\u2009min (2\u201312\u2009mg\/kg\/min). The primary outcome was baseline\u2010subtracted area under the curve for C\u2010peptide concentrations. Secondary outcomes included concentrations of plasma glucose, glucagon, glucose\u2010dependent insulinotropic polypeptide (GIP), glucagon\u2010like peptide 1 (GLP\u20101), carboxy\u2010terminal collagen crosslink (CTX), procollagen Type 1 amino\u2010terminal propeptide (P1NP) and serum triglycerides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty men (age: 24.9\u2009\u00b1\u20093.2\u2009years; BMI: 23.8\u2009\u00b1\u20091.5\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were included. Peak plasma oxytocin concentrations: 193\u2009\u00b1\u200929 and 401\u2009\u00b1\u200966\u2009pg\/mL. Circulating concentrations of plasma glucose, C\u2010peptide, glucagon, GIP, GLP\u20101, CTX, P1NP and triglyceride were similar across study visits. Neither oxytocin dose affected C\u2010peptide response or any secondary metabolic outcomes compared with placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute intravenous oxytocin infusion resulting in supraphysiological plasma concentrations did not modulate pancreatic or gut hormone secretion, or markers of bone turnover during a controlled, stepwise glucose challenge in healthy men, suggesting limited acute metabolic and skeletal effects of oxytocin under these conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71292","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:14:01Z","timestamp":1788423241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravenous Oxytocin Does Not Affect Glucose\u2010Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-930X","authenticated-orcid":false,"given":"Vivian","family":"Kliim\u2010Hansen","sequence":"first","affiliation":[{"name":"Center for Clinical Metabolic Research, Copenhagen University Hospital\u2014Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-6421","authenticated-orcid":false,"given":"Ida M.","family":"Gether","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Copenhagen University Hospital\u2014Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Copenhagen University Hospital\u2014Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Ellegaard","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Copenhagen University Hospital\u2014Herlev and Gentofte  Hellerup Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam G.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Copenhagen University Hospital\u2014Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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