{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:07:58Z","timestamp":1789711678123,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the relative importance of attributes driving obesity medication (OM) choice and preferences among individuals with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>US adults with obesity or overweight and \u2265\u20091 obesity\u2010related complication completed an online survey including a discrete\u2010choice experiment (DCE) in October\u2013November 2025. In the DCE, participants chose between 2 hypothetical, experimentally designed OM profiles with attributes\/levels related to efficacy, cardiovascular (CV) risk reduction, side effects, administration (route\/frequency), and dosing instruction requirements. In a fixed\u2010choice comparison, participants chose between 2 predefined oral OM profiles. Relative preference weights for the DCE attribute levels were estimated using a random\u2010parameters logit model to estimate attribute importance, tradeoffs, and predicted treatment choice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 800 participants (400 OM\u2010na\u00efve\/400 OM\u2010experienced, 400 injection\u2010na\u00efve\/400 injection\u2010experienced), the most important attributes were route of administration, average weight\u2010loss percentage, CV risk reduction, and the proportion of people achieving \u2265\u200920% weight loss. Dosing instructions had the lowest relative importance. There was a preference for 1 OM profile (Treatment A\u2014a hypothetical oral semaglutide\u2010like profile) over the alternative OM profile (Treatment B\u2014a hypothetical orforglipron\u2010like profile), according to the responses from the DCE (84.2% vs. 15.8%) and the fixed\u2010choice question (90.0% vs. 10.0%). Only 23.4% indicated that taking an OM treatment on an empty stomach and waiting 30\u2009min to eat would be disruptive to their lives. Most (73.3%) OM\u2010na\u00efve participants were open to taking an oral OM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with overweight or obesity prioritise weight\u2010loss efficacy, CV risk reduction, and oral administration in OM treatment decisions; dosing instruction requirements were of low importance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71318","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:30:09Z","timestamp":1789709409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preferences for Obesity Medications Among People With Overweight or Obesity in the United States: A Discrete\u2010Choice Experiment (\n                    <scp>OPTIC<\/scp>\n                    )"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-0843","authenticated-orcid":false,"given":"Jaime P.","family":"Almandoz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-8089","authenticated-orcid":false,"given":"Beverly G.","family":"Tchang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0936-5677","authenticated-orcid":false,"given":"Kelley","family":"Myers","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-8397","authenticated-orcid":false,"given":"Andrea","family":"Traina","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-3571","authenticated-orcid":false,"given":"Jigish","family":"Bhavsar","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-7912","authenticated-orcid":false,"given":"Victoria","family":"Divino","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0331-7772","authenticated-orcid":false,"given":"Cannon","family":"Kent","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-5919","authenticated-orcid":false,"given":"Sara Tadesse","family":"Bell","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Endotext","author":"Tchang B. 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