{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:26:23Z","timestamp":1793759183051,"version":"4.6.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501013"],"award-info":[{"award-number":["82501013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271176"],"award-info":[{"award-number":["32271176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085QH261"],"award-info":[{"award-number":["2308085QH261"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aims<\/jats:title>\n To characterise fracture\u2010centred skeletal adverse\u2010event reporting across nine glucose\u2010lowering drug classes and test whether regional differences persist after separating Japan from non\u2010Japan Asian reporting contexts.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n We analysed\n FAERS<\/jats:styled-content>\n and\n JADER<\/jats:styled-content>\n reports, with fracture as the primary endpoint and reporting frequency per 10\u2009000 mapped suspect reports.\n FAERS<\/jats:styled-content>\n older age was harmonised to \u2265\u200960\u2009years, with \u2265\u200965 and \u2265\u200970\u2010year sensitivity analyses. Regional analyses separated Western, Japan, and non\u2010Japan Asia; class\u2010specific reporting odds were adjusted for age, sex, calendar year, and reporter type. Disproportionality analyses were supplementary.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study included 15\u2009473\u2009015\n FAERS<\/jats:styled-content>\n and 1\u2009037\u2009161\n JADER<\/jats:styled-content>\n reports, including 202\u2009881 and 10\u2009678 fractures. Using final deduplicated\n FAERS<\/jats:styled-content>\n denominators, fracture reporting was highest for insulin (126.08\/10000),\n DPP<\/jats:styled-content>\n \u20104 inhibitors (111.03) and sulfonylureas (103.76), whereas thiazolidinediones (152.54),\n SGLT2<\/jats:styled-content>\n inhibitors (115.14) and\n GLP<\/jats:styled-content>\n \u20101 receptor agonists (112.15) were most prominent in\n JADER<\/jats:styled-content>\n . Age was unavailable in 44.9% of unique\n FAERS<\/jats:styled-content>\n suspect reports, but findings were stable across age thresholds. Japan accounted for 83.0%\u201392.9% of total\u2010Asian fractures for thiazolidinediones,\n GLP<\/jats:styled-content>\n \u20101 receptor agonists,\n SGLT2<\/jats:styled-content>\n inhibitors and\n DPP<\/jats:styled-content>\n \u20104 inhibitors; corresponding non\u2010Japan Asian\n RFRs<\/jats:styled-content>\n were not clearly elevated. Insulin remained higher after excluding Japan (\n RFR<\/jats:styled-content>\n 1.96, 95%\n CI<\/jats:styled-content>\n 1.57\u20132.45). No class met\n FDR<\/jats:styled-content>\n \u2010positive fracture disproportionality criteria.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Skeletal reporting profiles varied by drug class, database, and reporting context. Apparent total\u2010Asian elevations for several classes were predominantly Japan\u2010driven and should not be interpreted as patient\u2010level Asian fracture risk.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.71319","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:14:48Z","timestamp":1789373688000},"page":"11310-11319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fracture\u2010Centred Skeletal Reporting Profiles of Glucose\u2010Lowering Drug Classes in\n FAERS<\/scp>\n and\n JADER<\/scp>\n : Cross\u2010Database and Regional Reporting\u2010Context Analyses"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-828X","authenticated-orcid":false,"given":"Bin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC Division of Life Sciences and Medicine, University of Science and Technology of China Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC Division of Life Sciences and Medicine, University of Science and Technology of China Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC Division of Life Sciences and Medicine, University of Science and Technology of China Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-024-00867-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-03926-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziae003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094827"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-025-01552-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147988"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-04070-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2024.09.028"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-024-01421-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdsfr.2023.1323057"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-024-01423-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004172"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.25106"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000041444"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.70062"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3780"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1357309"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-023-06908-2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-024-01518-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-025-02468-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102624"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.16775"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06493-9"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07227-w"}],"container-title":["Diabetes, 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