{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:22Z","timestamp":1792384882022,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK143312"],"award-info":[{"award-number":["K23DK143312"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR000445"],"award-info":[{"award-number":["UL1 TR000445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020194","name":"Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center","doi-asserted-by":"publisher","award":["P30 DK058404"],"award-info":[{"award-number":["P30 DK058404"]}],"id":[{"id":"10.13039\/100020194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      No studies have investigated the synergistic effectiveness of Glucagon\u2010Like Peptide 1 Receptor Agonists (GLP1RAs) in patients with persistent obesity following bariatric surgery. The GLP\u20101 Receptor Agonists Post\u2010Bariatric Surgery (GRABS) Trial aims to investigate the effectiveness of tirzepatide (TRZ) versus standard of care (SOC) after Roux\u2010en\u2010Y gastric bypass (RYGB) in patients with persistent obesity (body mass index [BMI] \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, open\u2010label proof\u2010of\u2010concept trial compares 24\u2009weeks of TRZ with SOC versus SOC alone after RYGB. The primary outcome is total percent weight change from baseline to 24\u2009weeks after trial initiation. Patients aged 25\u201365 with BMI \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      enroled 12\u2009months after RYGB are randomized 1:1 to 24\u2009weeks of TRZ or SOC. Exclusion criteria include: type 1 diabetes, type 2 diabetes treatment other than metformin, conversion to RYGB from prior bariatric surgery, and GLP1RA use in the past 3\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study enroled 33 patients, with 5 withdrawals prior to completing a baseline visit, resulting in a final sample of 28 patients. The final cohort is 82% female, 75% white, median age 42.0\u2009years, pre\u2010surgery BMI of 48.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , baseline BMI at randomization of 36.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and baseline weight of 95.6\u2009kg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GRABS is the first randomized trial to investigate GLP1RA effectiveness in patients with persistent obesity following RYGB, with the potential to inform synergistic adjuvant strategies to enhance surgical weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT06162715\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71320","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:58:28Z","timestamp":1788937108000},"page":"9861-9870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GLP<\/scp>\n                    \u20101 Receptor Agonists Post\u2010Bariatric Surgery (\n                    <scp>GRABS<\/scp>\n                    ) Trial: Rationale, Design and Baseline Characteristics"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-3117","authenticated-orcid":false,"given":"J. M.","family":"Samuels","sequence":"first","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1267-8464","authenticated-orcid":false,"given":"C. R.","family":"Williams","sequence":"additional","affiliation":[{"name":"Vanderbilt Medical Student Research Training Program Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H.","family":"Self","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Department of Surgery William S. Middleton VA  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roumie","sequence":"additional","affiliation":[{"name":"Department of Surgery William S. Middleton Veterans Health Administration Hospital  Madison Wisconsin USA"},{"name":"Tennessee Valley VA Health Care System  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Spann","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Northup","sequence":"additional","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Sylvester Comprehensive Cancer Center University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Irlmeier","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Sylvester Comprehensive Cancer Center University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Niswender","sequence":"additional","affiliation":[{"name":"Tennessee Valley VA Health Care System  Nashville Tennessee USA"},{"name":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism VUMC  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2704"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.19615"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u20109\u201088"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004358"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010021\u201000986\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2009.02.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010009\u20100060\u2010z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23371"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.2229"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.20313"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2024.7052"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.03.034"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010019\u201004022\u2010z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrac145"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004369"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002026\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201004071\u20101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30157\u20103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.2930"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010026\u201004416\u20104"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15737"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2025.02.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010025\u201008414\u20102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2015.06.001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.273.4.G920"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh0980"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12087"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20791"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.5025"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106450"},{"key":"e_1_2_10_34_1","unstructured":"National Cancer Institute \u201cLearn About Randomization \u201d(2024) https:\/\/ctrandomization.cancer.gov\/about\/."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.12.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.028381"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2022.04.012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.24288"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.24945"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010026\u201008795\u2010y"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00316\u20104"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:19:38Z","timestamp":1792383578000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/dom.71320"],"URL":"https:\/\/doi.org\/10.1111\/dom.71320","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71320\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71320\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"2026-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}