{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:04:01Z","timestamp":1789963441075,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the effect of semaglutide on body composition and physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The phase 3b STEP UP trial randomised adults with body mass index \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      to once\u2010weekly subcutaneous semaglutide 7.2\u2009mg, semaglutide 2.4\u2009mg or placebo for 72\u2009weeks. This prespecified secondary analysis assessed changes in MRI body composition and physical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1407 participants, 55 with a valid baseline scan were included (semaglutide 7.2\u2009mg,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943, 2.4\u2009mg,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 [pooled semaglutide group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949]; placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Estimated treatment differences (95% confidence intervals;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values) for absolute changes in adipose\/muscle compartment volumes for the pooled semaglutide versus placebo group, respectively, were: \u221211.1\u2009L (\u221216.5 to \u22125.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) for adipose body tissue, \u22121.5\u2009L (\u22122.9 to \u22120.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) for visceral adipose tissue, \u22121.7\u2009L (\u22124.0 to 0.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16) for lean body tissue, \u22121.1\u2009L (\u22122.3 to 0.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07) for thigh skeletal muscle volume and \u22120.92%\u2010points (\u22121.41 to \u22120.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) for thigh muscle fat infiltration. Similar results were seen for relative changes in adipose\/muscle compartment volumes. A sensitivity analysis for the semaglutide 7.2\u2009mg group versus placebo showed similar results. A mean of 13 sit\u2010to\u2010stand repetitions in 30\u2009s at baseline, and 15 repetitions at Week 72, was observed in the pooled semaglutide and placebo groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide plus lifestyle intervention was associated with reductions in adipose tissue volume, skeletal muscle volume and skeletal muscle fat infiltration, with a preserved number of sit\u2010to\u2010stand repetitions. Further research to assess the impact of weight loss on skeletal muscle composition and function should be explored in the future.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier NCT05646706\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71323","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:38:07Z","timestamp":1789961887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Semaglutide on Thigh Skeletal Muscle Volume, Fat Infiltration and Physical Function in People With Obesity: Secondary Analysis of\n                    <scp>STEP UP<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-0562","authenticated-orcid":false,"given":"J\u00f8ran","family":"Hjelmes\u00e6th","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Obesity and Nutrition Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine, Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhas","family":"Bhat","sequence":"additional","affiliation":[{"name":"Novo Nordisk Global Business Services  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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