{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:15:03Z","timestamp":1791472503471,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009164","name":"Transnationale Universiteit Limburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>UBT251 is a novel triple agonist peptide targeting the glucagon\u2010like peptide\u20101 (GLP\u20101), glucose\u2010dependent insulinotropic polypeptide (GIP) and glucagon receptors. This first\u2010in\u2010human Phase 1a\/1b study evaluated the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of UBT251.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This randomized, double\u2010blind, placebo\u2010controlled study consisted of two clinical trials. The Phase 1a study was a single\u2010ascending\u2010dose trial, in which participants received a single subcutaneous injection of UBT251 at doses ranging from 0.1 to 4.5\u2009mg. The Phase 1b study was a multiple\u2010ascending\u2010dose trial conducted in participants with overweight or obesity without diabetes. UBT251 was administered once weekly by subcutaneous injection for 12 consecutive weeks. Safety and tolerability were the primary endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UBT251 was generally well tolerated, with laboratory investigations, decreased appetite and gastrointestinal adverse events being the most common adverse effects. In participants with overweight or obesity, once\u2010weekly subcutaneous injections of UBT251 at doses of 1, 3 and 6\u2009mg for 12\u2009weeks led to a mean body weight reduction of 8.96\u201313.48\u2009kg, compared with the 1.57\u2009kg increase observed in the placebo group. Following single and multiple dosing, UBT251 exhibited approximately linear pharmacokinetics across the 1.0\u20136.0\u2009mg dose range. UBT251 treatment also demonstrated favourable metabolic effects, including reductions in fasting plasma glucose, haemoglobin A1c and lipid parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UBT251 demonstrated an acceptable safety profile and predictable pharmacokinetic properties, accompanied by substantial weight reduction and meaningful metabolic improvements. These findings strongly support the continued clinical development of UBT251 as a potential therapeutic option for obesity and type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      ChiCTR2600116148 and ChiCTR2600123803 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/\">https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71327","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:07:49Z","timestamp":1788934069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety, Pharmacokinetics and Pharmacodynamics of the\n                    <scp>GLP<\/scp>\n                    \u20101\/\n                    <scp>GIP<\/scp>\n                    \/\n                    <scp>GCG<\/scp>\n                    Receptor Agonist\n                    <scp>UBT251<\/scp>\n                    Injection: A Randomized, Placebo\u2010Controlled Phase 1a\/1b Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-586X","authenticated-orcid":false,"given":"Guo\u2010ping","family":"Yang","sequence":"first","affiliation":[{"name":"Center of Clinical Pharmacology, the Third Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology, the Third Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Xiangya School of 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Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The United Laboratories International Holdings Limited (TUL)  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Su","sequence":"additional","affiliation":[{"name":"The United Laboratories International Holdings Limited (TUL)  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010xiu","family":"Xu","sequence":"additional","affiliation":[{"name":"The United Laboratories International Holdings Limited (TUL)  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"The United Bio\u2010Technology (Hengqin) Co., Ltd  Zhuhai 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