{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:02:15Z","timestamp":1789437735953,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1000986"],"award-info":[{"award-number":["APP1000986"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1129592"],"award-info":[{"award-number":["APP1129592"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2009577"],"award-info":[{"award-number":["APP2009577"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2008702"],"award-info":[{"award-number":["APP2008702"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1153420"],"award-info":[{"award-number":["APP1153420"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The interplay between obesity and physical performance in women is poorly understood, especially before the fifties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess associations between weight gain from early to mid\u2010adulthood and midlife performance\u2010based physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>499 women from the Menarche\u2010to\u2010PreMenopause Study completed handgrip strength, chair rise, and standing balance tests at age 41\u201348. The lowest tertile was defined as the \u2018worse performance\u2019 group. Weight and height were self\u2010reported across eight surveys, from ages 18\u201323 to 40\u201345, and used to determine body mass index (BMI) trajectories using group\u2010based trajectory modelling, as well as to estimate annual weight gain percentages. Other obesity indicators included BMI, waist circumference (WC), and waist\u2010to\u2010hip ratio (WHR) measured cross\u2010sectionally at age 41\u201348.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two BMI trajectories were identified: Normal\u2010Increasing (75%) and High\u2010Increasing (25%). The High\u2010Increasing BMI trajectory showed approximately 40% higher prevalence of worse chair\u2010rise and standing\u2010balance performances compared to the Normal\u2010Increasing group (95% CI: 9%\u201384%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01; and 10%\u201384%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Higher annual weight gain percentage showed a prevalence ratio (PR) 1.21 times higher for worse standing balance performance (95% CI: 1.06\u20131.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Midlife obesity (BMI \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), high\u2010risk WC (\u2265\u200980\u2009cm) and WHR (\u2265\u20090.8) were also associated with a higher prevalence of worse performance on the chair rise and standing balance tests, with PRs from 1.41 to 1.55. No consistent evidence was found for handgrip strength.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weight gain from early to mid\u2010adulthood was associated with worse performance on the chair rise and standing balance tests in midlife, highlighting the potential of early weight\u2010control strategies to preserve midlife performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71349","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:05:07Z","timestamp":1789434307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesity and Midlife Performance: A Cross\u2010Sectional and Longitudinal Analysis of Women in the Menarche\u2010To\u2010\n                    <scp>PreMenopause<\/scp>\n                    Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-1894","authenticated-orcid":false,"given":"Leticia W.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Australian Women and Girls' Health Research Centre, School of Public Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-9308","authenticated-orcid":false,"given":"Jenny","family":"Doust","sequence":"additional","affiliation":[{"name":"Australian Women and Girls' Health Research Centre, School of Public Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-2715","authenticated-orcid":false,"given":"Gregore I.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Australian Women and Girls' Health Research Centre, School of Public Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-5904","authenticated-orcid":false,"given":"Gita D.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Australian Women and Girls' Health Research Centre, School of Public Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Commonwealth of Australia \u201cThe National Obesity Strategy 2022\u20132032\u201d (2022)."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)00355\u20101"},{"key":"e_1_2_11_4_1","volume-title":"Overweight and Obesity","author":"Australian Institute of Health and Welfare","year":"2022"},{"key":"e_1_2_11_5_1","volume-title":"OECD Health Statistics","author":"Organisation for Economic 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