{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:51:41Z","timestamp":1791359501821,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter, randomised, open\u2010label, active\u2010controlled Phase III trial was conducted at 30 centers in China. Adults aged 18\u201375\u2009years with obesity (BMI \u2265\u200928\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and without diabetes were randomised 1:1 to receive once\u2010weekly subcutaneous HD1916 or semaglutide for 44\u2009weeks. The primary endpoint was the percentage change in body weight from baseline to week 44. Equivalence was established if the 95% confidence interval (CI) of the between\u2010group difference was within the prespecified margin of \u00b14.16%. Key secondary endpoints included the proportions of participants achieving \u2265\u20095% and \u2265\u200910% weight loss and change in waist circumference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 462 participants were randomised (231 per group). At week 44, mean body weight decreased by 13.1% with HD1916 and 14.4% with semaglutide. The estimated treatment difference was 1.35% (95% CI, \u22120.02 to 2.72), which fell within the equivalence margin, confirming therapeutic equivalence. Proportions of participants achieving \u2265\u20095% weight loss (87.8% vs. 90.5%) and \u2265\u200910% weight loss (68.7% vs. 73.6%), as well as reductions in waist circumference, were comparable between groups. Any\u2010grade treatment\u2010emergent adverse events occurred in 86.5% and 89.2% of participants in the HD1916 and semaglutide groups, respectively; most were Grade 1\u20132.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HD1916 demonstrated equivalent body weight reductions to the reference product semaglutide (Wegovy), with a comparable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71354","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:57Z","timestamp":1791357057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Chemically Synthesized Semaglutide Injection (\n                    <scp>HD1916<\/scp>\n                    ) for the Treatment of Obesity: A Multicenter, Randomized, Phase\n                    <scp>III<\/scp>\n                    Trial"],"prefix":"10.1111","author":[{"given":"Leili","family":"Gao","sequence":"first","affiliation":[{"name":"Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of He'nan University of Science and Technology  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Li","sequence":"additional","affiliation":[{"name":"Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Guo","sequence":"additional","affiliation":[{"name":"Chongqing University Three Gorges Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jin","sequence":"additional","affiliation":[{"name":"Meihe Hospital the First Hospital of Jilin University (Meihekou Central Hospital)  Meihekou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Zunyi  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"He","sequence":"additional","affiliation":[{"name":"CSPC Baike (Shandong) Biopharmaceutical Co. 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