{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:09:17Z","timestamp":1789711757662,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930019"],"award-info":[{"award-number":["81930019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470900"],"award-info":[{"award-number":["82470900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232230"],"award-info":[{"award-number":["7232230"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Fatty liver diseases are severe and increasingly global pandemic resulted from metabolic diseases including metabolic dysfunction\u2013associated fatty liver disease (MAFLD) and type 2 diabetes mellitus (T2DM). Mitochondrial function is a critical factor in the pathogenesis and advancement of these diseases. Our previous results revealed that KCNH6 gene is associated with hyperinsulinemia and hyperglycemia in both humans and mice. In this study, we aim to detect the precise function of KCNH6 in hepatic lipid metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We used whole\u2010body Kcnh6 knockout (KO) mice as model mice and fed the mice a standard chow diet (SD) and\/or high\u2010fat diet (HFD) to evaluate the responsiveness of the liver. Glucose and lipid metabolisms were detected in mice. Genes participating in cholesterol biosynthesis and fatty acid \u03b2\u2010oxidation pathways were also evaluated using Western blot and qPCR experiments. Metabolic cage and seahorse metabolic flux were conducted to confirm mitochondrial function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>KCNH6 knockout impaired glucose metabolism through the AKT pathway. KCNH6 deficiency caused increased obesity and aggravated insulin resistance. KO mice exhibited aggravated HFD\u2010induced hepatic steatosis, which was associated with dysregulation of the ACC\u03b1 signaling pathway. Genetic ablation of KCNH6 resulted in altered expression profiles of genes participating in cholesterol biosynthesis and fatty acid \u03b2\u2010oxidation pathways. KCNH6 knockout also altered cholesterol synthesis and \u03b2\u2010oxidation of fatty acids. In addition, KCNH6 loss impaired energy metabolism and mitochondrial function. Mechanistically, KCNH6 knockout increased inflammation via NF\u2010\u03baB signaling pathway through interaction with IKK\u03b2 directly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, our data showed that KCNH6 exerts an important role in the regulation of hepatic lipid metabolism through mitochondrial functional pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71362","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:38:08Z","timestamp":1789709888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>KCNH6<\/scp>\n                    Controls Hepatic Lipid Metabolism by Regulating Mitochondrial Function Associated With\n                    <scp>IKK\u03b2<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Activation"],"prefix":"10.1111","author":[{"given":"Ru\u2010Xuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Department of Endocrinology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-7833","authenticated-orcid":false,"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Ran","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-5260","authenticated-orcid":false,"given":"Gang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-2149","authenticated-orcid":false,"given":"Jin\u2010Kui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrendo.2012.199","article-title":"Global Obesity: Trends, Risk Factors and Policy Implications","volume":"9","author":"Malik V. S.","year":"2013","journal-title":"Nature Reviews. Endocrinology"},{"issue":"4","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00132577-200512000-00018","article-title":"Diagnosis and Management of the Metabolic Syndrome","volume":"4","author":"NA","year":"2005","journal-title":"Critical Pathways in Cardiology: A Journal of Evidence\u2010Based Medicine"},{"issue":"10319","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(21)01701-3","article-title":"The EASL\u2010Lancet Liver Commission: Protecting the Next Generation of Europeans Against Liver Disease Complications and Premature Mortality","volume":"399","author":"Karlsen T. H.","year":"2022","journal-title":"Lancet"},{"issue":"4","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-0033-1358521","article-title":"The Lipid Droplet as a Potential Therapeutic Target in NAFLD","volume":"33","author":"Goh V.","year":"2013","journal-title":"Seminars in Liver Disease"},{"issue":"1","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41575-021-00523-4","article-title":"Advancing the Global Public Health Agenda for NAFLD: A Consensus Statement","volume":"19","author":"Lazarus J. V.","year":"2022","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"6","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/00000441-200512000-00011","article-title":"Nonalcoholic Steatohepatitis and the Metabolic Syndrome","volume":"330","author":"Neuschwander\u2010Tetri B. A.","year":"2005","journal-title":"American Journal of the Medical Sciences"},{"issue":"9","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jnutbio.2007.10.001","article-title":"The Role of Fatty Acids in the Development and Progression of Nonalcoholic Fatty Liver Disease","volume":"19","author":"Gentile C. L.","year":"2008","journal-title":"Journal of Nutritional Biochemistry"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3892\/etm.2015.2925","article-title":"MRI Chemical Shift Imaging of the Fat Content of the Pancreas and Liver of Patients With Type 2 Diabetes Mellitus","volume":"11","author":"Chai J.","year":"2016","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"5","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/meta.2001.22565","article-title":"Effects of Free Fatty Acids on Beta\u2010Cell Functions: A Possible Involvement of Peroxisome Proliferator\u2010Activated Receptors Alpha or Pancreatic\/Duodenal Homeobox","volume":"50","author":"Yoshikawa H.","year":"2001","journal-title":"Metabolism, Clinical and Experimental"},{"issue":"1","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.etp.2008.12.008","article-title":"Adipose Tissue, Liver and Pancreas Structural Alterations in C57BL\/6 Mice Fed High\u2010Fat\u2010High\u2010Sucrose Diet Supplemented With Fish Oil (n\u20103 Fatty Acid Rich Oil)","volume":"62","author":"Nascimento F. A.","year":"2010","journal-title":"Experimental and Toxicologic Pathology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1073\/pnas.91.23.10878","article-title":"Beta\u2010Cell Lipotoxicity in the Pathogenesis of Non\u2010Insulin\u2010Dependent Diabetes Mellitus of Obese Rats: Impairment in Adipocyte\u2010Beta\u2010Cell Relationships","volume":"91","author":"Lee Y.","year":"1994","journal-title":"National Academy of Sciences of the United States of America"},{"issue":"2","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial Alterations in Fatty Liver Diseases","volume":"78","author":"Fromenty B.","year":"2023","journal-title":"Journal of Hepatology"},{"issue":"4","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"e23486","DOI":"10.1096\/fj.202301957RR","article-title":"Mitochondrial Function and Reactive Oxygen Species Production During Human Sperm Capacitation: Unraveling Key Players","volume":"38","author":"Irigoyen P.","year":"2024","journal-title":"FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"issue":"6","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s11596-025-00143-y","article-title":"PPA1 Facilitates Thermogenesis in Brown and Beige Fat by Regulating the Mitochondrial Localization of FUS","volume":"45","author":"Sun Y.","year":"2025","journal-title":"Current Medical Science"},{"issue":"10","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105220","article-title":"Inhibition of Mitochondrial Fatty Acid Beta\u2010Oxidation Activates mTORC1 Pathway and Protein Synthesis via Gcn5\u2010Dependent Acetylation of Raptor in Zebrafish","volume":"299","author":"Zhou W. H.","year":"2023","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41418-020-00657-z","article-title":"Functions of Outer Mitochondrial Membrane Proteins: Mediating the Crosstalk Between Mitochondrial Dynamics and Mitophagy","volume":"28","author":"Xian H.","year":"2021","journal-title":"Cell Death and Differentiation"},{"issue":"13","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1016\/j.celrep.2018.12.005","article-title":"From Hyper\u2010 To Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion","volume":"25","author":"Yang J.\u2010K.","year":"2018","journal-title":"Cell Reports"},{"issue":"11","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1096\/fj.202001218R","article-title":"KCNH6 Protects Pancreatic Beta\u2010Cells From Endoplasmic Reticulum Stress and Apoptosis","volume":"34","author":"Lu J.","year":"2020","journal-title":"FASEB Journal"},{"issue":"9","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1055\/a-1177-6814","article-title":"Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism","volume":"52","author":"Lu J.","year":"2020","journal-title":"Hormone and Metabolic Research"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1011238","article-title":"Cisapride Induced Hypoglycemia via the KCNH6 Potassium Channel","volume":"13","author":"Lu J.","year":"2022","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"1","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1038\/s41467-021-25952-2","article-title":"Berberine Is an Insulin Secretagogue Targeting the KCNH6 Potassium Channel","volume":"12","author":"Zhao M. M.","year":"2021","journal-title":"Nature Communications"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3739556","article-title":"KCNH6 Enhanced Hepatic Glucose Metabolism Through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition","volume":"2022","author":"Zhang Y. C.","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","DOI":"10.2337\/db20-1854-P","article-title":"1854\u2010P: Kcnh6 Improves Glucose Metabolism by Inhibiting Oxidative Stress","volume":"69","author":"Lu J.","year":"2020","journal-title":"Diabetes"},{"issue":"1","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","DOI":"10.2337\/db23-1597-P","article-title":"1597\u2010P: KCNH6 Regulates Hepatic Mitochondrial Function and Glucose Metabolism via NF\u2010\u03baB Pathway","volume":"72","author":"Zhao R.","year":"2023","journal-title":"Diabetes"},{"issue":"4","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nmeth.2374","article-title":"TALEN\u2010Mediated Precise Genome Modification by Homologous Recombination in Zebrafish","volume":"10","author":"Zu Y.","year":"2013","journal-title":"Nature Methods"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18134","article-title":"HID\u20101 Is Required for Homotypic Fusion of Immature Secretory Granules During Maturation","volume":"5","author":"Wen D.","year":"2016","journal-title":"eLife"},{"issue":"1","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00018-025-05933-0","article-title":"The Contrasting Effects of Two Antimalarial Drugs on Insulin Secretion","volume":"82","author":"Lu J.","year":"2025","journal-title":"Cellular and Molecular Life Sciences"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101885","article-title":"All\u2010Potassium Channel CRISPR Screening Reveals a Lysine\u2010Specific Pathway of Insulin Secretion","volume":"80","author":"Lu J.","year":"2024","journal-title":"Molecular Metabolism"},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-59745-019-5_13","article-title":"Isolation and Culture of Adult Mouse Hepatocytes","volume":"633","author":"Li W. C.","year":"2010","journal-title":"Methods in Molecular Biology"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jare.2024.01.028","article-title":"Dehydrocostus Lactone Suppresses Gastric Cancer Progression by Targeting ACLY to Inhibit Fatty Acid Synthesis and Autophagic Flux","volume":"67","author":"Chen Y.","year":"2025","journal-title":"Journal of Advanced Research"},{"issue":"2","key":"e_1_2_12_32_1","first-page":"T1","article-title":"Insulin Signaling, Resistance, and Metabolic Syndrome: Insights From Mouse Models Into Disease Mechanisms","volume":"220","author":"Shaodong G.","year":"2014","journal-title":"Journal of Endocrinology"},{"issue":"1","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.1806","article-title":"A Guide to Analysis of Mouse Energy Metabolism","volume":"9","author":"Tschop M. H.","year":"2011","journal-title":"Nature Methods"},{"issue":"4","key":"e_1_2_12_34_1","article-title":"Rodent Models for Metabolic Syndrome Research","volume":"2011","author":"Panchal S. K.","year":"2011","journal-title":"Journal of Biomedicine & Biotechnology"},{"issue":"1","key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2013.05.013","article-title":"Today's and Yesterday's of Pathophysiology: Biochemistry of Metabolic Syndrome and Animal Models","volume":"30","author":"Aydin S.","year":"2014","journal-title":"Nutrition"},{"issue":"12","key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1210\/en.2008-0354","article-title":"Analysis of Lysophosphatidic Acid (LPA) Receptor and LPA\u2010Induced Endometrial Prostaglandin\u2010Endoperoxide Synthase 2 Expression in the Porcine Uterus","volume":"149","author":"Seo H.","year":"2008","journal-title":"Endocrinology"},{"issue":"10","key":"e_1_2_12_37_1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.freeradbiomed.2009.08.014","article-title":"Oxidant Stress\u2010Induced Loss of IRS\u20101 and IRS\u20102 Proteins in Rat Skeletal Muscle: Role of p38 MAPK","volume":"47","author":"Archuleta T. L.","year":"2009","journal-title":"Free Radical Biology & Medicine"},{"issue":"1","key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"E154","DOI":"10.1152\/ajpendo.00330.2005","article-title":"Muscle Glycogen Inharmoniously Regulates Glycogen Synthase Activity, Glucose Uptake, and Proximal Insulin Signaling","volume":"290","author":"Jensen J.","year":"2006","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"1","key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2337\/diabetes.54.1.8","article-title":"Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes","volume":"54","author":"Ritov V. B.","year":"2005","journal-title":"Diabetes"},{"issue":"3","key":"e_1_2_12_40_1","first-page":"223","article-title":"Impaired Mitochondrial Activity in the Insulin\u2010Resistant Offspring of Patients With Type 2 Diabetes. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. N Engl J Med 2004; 350: 664\u201071","volume":"9","author":"Razak F.","year":"2004","journal-title":"Vascular Medicine"},{"issue":"4","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.26226","article-title":"Mitochondrial Adaptations and Dysfunctions in Nonalcoholic Fatty Liver Disease","volume":"58","author":"Begriche K.","year":"2013","journal-title":"Hepatology"},{"issue":"5","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/hep.29025","article-title":"Targeting the Mitochondrial Pyruvate Carrier Attenuates Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis","volume":"65","author":"McCommis K. S.","year":"2017","journal-title":"Hepatology"},{"issue":"12","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.7150\/thno.42658","article-title":"PTPROt Aggravates Inflammation by Enhancing NF\u2010kappaB Activation in Liver Macrophages During Nonalcoholic Steatohepatitis","volume":"10","author":"Jin K.","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"e_1_2_12_44_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The Nuclear Factor NF\u2010kappaB Pathway in Inflammation","volume":"1","author":"Lawrence T.","year":"2009","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"5","key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ccell.2015.10.001","article-title":"NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity\u2010Mediated Hepatocyte Apoptosis","volume":"28","author":"Kondylis V.","year":"2015","journal-title":"Cancer Cell"},{"issue":"3","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/hep.26751","article-title":"Interferon Regulatory Factor 3 Constrains IKKbeta\/NF\u2010kappaB Signaling to Alleviate Hepatic Steatosis and Insulin Resistance","volume":"59","author":"Wang X. A.","year":"2014","journal-title":"Hepatology"},{"issue":"12","key":"e_1_2_12_47_1","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jc.2006-0587","article-title":"Review: The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease","volume":"91","author":"Utzschneider K. M.","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2337\/dc07-1338","article-title":"Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults","volume":"31","author":"Fleischman A.","year":"2008","journal-title":"Diabetes Care"},{"issue":"5535","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","article-title":"Reversal of Obesity\u2010 and Diet\u2010Induced Insulin Resistance With Salicylates or Targeted Disruption of Ikkbeta","volume":"293","author":"Yuan M.","year":"2001","journal-title":"Science"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:38:14Z","timestamp":1789709894000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":48,"alternative-id":["10.1111\/dom.71362"],"URL":"https:\/\/doi.org\/10.1111\/dom.71362","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dom.71362"}}