{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:01:18Z","timestamp":1790233278842,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the real\u2010world effectiveness of the Reducing Weight With Intensive Dietary Support (REWIND) programme, offering total diet replacement or low carbohydrate diet pathways, on weight loss, glycaemic control, glucose\u2010lowering medication prescribing and remission of Type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted an observational, pre\u2013post quasi\u2010experimental analysis using primary care electronic health records from North West London. REWIND participants with \u2265\u200912\u2009months of follow\u2010up (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091051) were compared with eligible individuals who were not referred to the programme (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966\u2009376). Inverse probability weighting was used to adjust for baseline group differences and outcomes estimated as average treatment effects on the treated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 12\u2009months, REWIND participation was associated with greater weight loss (\u22122.1\u2009kg [95% CI: \u22122.7 to \u22121.5]), reduced glucose\u2010lowering medication prescribing (\u221212.2% [\u221213.1 to \u221211.3]) and increased remission (+4.2% [3.9\u20134.5]) compared with controls, but no significant difference in glycaemic control. The increase in remission was greater among participants following the total diet replacement pathway (+6.9% [6.1\u20136.8]) than the low\u2010carbohydrate pathway (+2.9% [2.6\u20133.2]). Programme completers experienced greater improvements across outcomes, including an +8.1% (7.8%, 8.5%) increase in remission compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Participation in REWIND was associated with modest improvements in weight, medication use and diabetes remission compared with usual care. Greater improvements among programme completers suggest that sustaining engagement is an important challenge in achieving benefits from similar programmes in routine care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71364","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:13:57Z","timestamp":1790230437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Effectiveness of the Reducing Weight With Intensive Dietary Support (\n                    <scp>REWIND<\/scp>\n                    ) Programme on Type 2 Diabetes Remission"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8642-0280","authenticated-orcid":false,"given":"Ben","family":"Griffiths","sequence":"first","affiliation":[{"name":"Imperial College London, School of Public Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Mehar","sequence":"additional","affiliation":[{"name":"NHS North West London Collaboration of Clinical Commissioning Groups  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Blangiardo","sequence":"additional","affiliation":[{"name":"Imperial College London, School of Public Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bottle","sequence":"additional","affiliation":[{"name":"Imperial College London, School of Public Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Misra","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Department of Diabetes and Endocrinology Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Morganstein","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Chelsea and Westminster NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Willis","sequence":"additional","affiliation":[{"name":"NHS North West London Collaboration of Clinical Commissioning Groups  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Gregg","sequence":"additional","affiliation":[{"name":"Imperial College London, School of Public Health  London UK"},{"name":"Royal College of Surgeons of Ireland University of Medicine and Health Sciences, R.O.I, School of Population Health  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Diabetes UK \u201cNumber of People Living With Diabetes in the UK Tops 5 Million for the First Time \u201d2023 accessed August 3 2023 https:\/\/www.diabetes.org.uk\/about_us\/news\/number\u2010people\u2010living\u2010diabetes\u2010uk\u2010tops\u20105\u2010million\u2010first\u2010time#:~:text=Our%20new%20figures%20show%20that 2%20diabetes%20in%20the%20UK."},{"key":"e_1_2_10_3_1","unstructured":"Diabetes UK \u201c1\u2010in\u201010 Adults Living With Diabetes by 2030 \u201d2023 accessed August 7 2023 https:\/\/www.diabetes.org.uk\/about_us\/news\/1\u201010\u2010adults\u2010living\u2010diabetes\u20102030."},{"issue":"21","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1001\/jama.281.21.2005","article-title":"Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus: Progressive Requirement for Multiple Therapies (UKPDS 49)","volume":"281","author":"Turner R. 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K.","year":"2012","journal-title":"Health Affairs"},{"issue":"9","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S2213-8587(24)00194-3","article-title":"Early Findings From the NHS Type 2 Diabetes Path to Remission Programme: A Prospective Evaluation of Real\u2010World Implementation","volume":"12","author":"Valabhji J.","year":"2024","journal-title":"Lancet Diabetes & Endocrinology"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ypmed.2017.04.022","article-title":"Behavioral Lifestyle Interventions for Moderate and Severe Obesity: A Systematic Review","volume":"100","author":"Lv N.","year":"2017","journal-title":"Preventive Medicine"},{"issue":"8","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","DOI":"10.1111\/dme.14395","article-title":"Predictors of Type 2 Diabetes Remission in the Diabetes Remission Clinical Trial (DiRECT)","volume":"38","author":"Thom G.","year":"2021","journal-title":"Diabetic Medicine"},{"issue":"17","key":"e_1_2_10_26_1","first-page":"1566","article-title":"Long\u2010Term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus: Four\u2010Year Results of the Look AHEAD Trial","volume":"170","author":"Group LAR","year":"2010","journal-title":"Archives of Internal Medicine"},{"issue":"2","key":"e_1_2_10_27_1","article-title":"Long\u2010Term Non\u2010Pharmacological Weight Loss Interventions for Adults With Type 2 Diabetes Mellitus","author":"Norris S. 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