{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:42:57Z","timestamp":1792438977108,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019009","name":"Fondation Francophone pour la Recherche sur le Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Inaugural presentation at type 1 diabetes onset, as ketoacidosis, has been associated with poorer glycaemic control, but its relationship to diabetes\u2010related complications remains unclear. We assessed the association between inaugural intensive care unit (ICU) admission and long\u2010term diabetes\u2010related outcomes in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional analysis used data from the Soci\u00e9t\u00e9 Francophone du Diab\u00e8te\u2014Cohorte Diab\u00e8te de Type 1 (SFDT1) cohort. We compared participants with and without an inaugural ICU admission regarding chronic complications, recent acute events, and cardiometabolic risk factors. Models were adjusted for age, sex, diabetes duration, smoking status, socioeconomic vulnerability, education, insulin therapy, HbA1c, and centre; interaction terms were tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3548 adults with type 1 diabetes (median duration 20\u2009years [IQR 10\u201330]), 377 (10.6%) reported inaugural ICU admission. Retinopathy was more prevalent in the ICU group (36.6 vs. 31.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), including proliferative forms (11.1 vs. 7.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). These differences remained significant after adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). An association with retinopathy was observed among individuals diagnosed before the age of 17 (OR\u2009=\u20091.5; 95% CI, 1.1\u20132.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Severe hypoglycaemia in the previous year was more frequent in the ICU group (15.4% vs. 10.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and remained significant after adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No significant differences were observed for the other variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicentre cohort of adults with long\u2010standing type 1 diabetes, inaugural ICU was associated with at least a 50% higher odds of severe hypoglycaemia and retinopathy, including proliferative forms. The association with retinopathy was mainly observed among individuals diagnosed at a young age.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT04657783)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71393","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:41:46Z","timestamp":1790926906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Chronic Complications After Inaugural Admission in Intensive Care Unit for Type 1 Diabetes in the\n                    <scp>SFDT1<\/scp>\n                    Cohort: The\n                    <scp>INAUGURAL<\/scp>\n                    Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-3385","authenticated-orcid":false,"given":"Emmanuel","family":"Cosson","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, Avicenne Hospital Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Bobigny France"},{"name":"Clinical Research Center in Human Nutrition (CRNH\u2010IdF), \u00cele\u2010de\u2010France Nord Specialized Center for Obesity (CSO) University Sorbonne Paris Nord  Bobigny France"},{"name":"Nutritional Epidemiology Research Team (EREN), Center for Research in Epidemiology and Statistics (CRESS) University Sorbonne Paris Nord and Paris Cit\u00e9 University, INSERM, INRAE, CNAM  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-1664","authenticated-orcid":false,"given":"Gloria","family":"Aguayo","sequence":"additional","affiliation":[{"name":"Department of Precision Health, Deep Digital Phenotyping Unit Luxembourg Institute of Health  Strassen Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-7085","authenticated-orcid":false,"given":"Amandine","family":"Cr\u00e9quer\u2010Grandhomme","sequence":"additional","affiliation":[{"name":"Sanofi  Gentilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-5059","authenticated-orcid":false,"given":"Amar","family":"Bahloul","sequence":"additional","affiliation":[{"name":"Sanofi  Gentilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology Montpellier University Hospital, University of Montpellier, INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-7360","authenticated-orcid":false,"given":"Louis","family":"Potier","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology, Bichat Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-5531","authenticated-orcid":false,"given":"Pauline","family":"Schaepelynck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology European Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-897X","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Sola\u2010Gazagnes","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Cochin Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8198-7674","authenticated-orcid":false,"given":"Anne","family":"Spiteri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetology, Ambulatory Care Platform Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-0741","authenticated-orcid":false,"given":"Jean\u2010Pierre","family":"Riveline","sequence":"additional","affiliation":[{"name":"Service de Diab\u00e8tes et Endocrinologie, H\u00f4pital Lariboisi\u00e8re AP\u2010HP  Paris France"},{"name":"\u00c9quipe Immunit\u00e9 et M\u00e9tabolisme du Diab\u00e8te Universit\u00e9 Paris Cit\u00e9, INSERM UMR\u2010S1151, CNRS UMR\u2010S8253, Institut Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-5966","authenticated-orcid":false,"given":"Guy","family":"Fagherazzi","sequence":"additional","affiliation":[{"name":"Department of Precision Health, Deep Digital Phenotyping Unit Luxembourg Institute of Health  Strassen 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