{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:03:31Z","timestamp":1790741011639,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dual glucagon\u2010like peptide\u20101\/glucagon receptor (GLP\u20101\/GCGR) agonists represent a novel obesity treatment class, but existing meta\u2010analyses often conflate them with GIP\u2010containing agents (tirzepatide, retatrutide) or restrict analysis to one or two drugs, leaving class\u2010specific efficacy and safety incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We systematically searched PubMed, Embase, Cochrane Library, Scopus and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      through 20 July 2026 for randomized controlled trials of mazdutide, survodutide, cotadutide, and efinopegdutide in adults with overweight\/obesity (PROSPERO CRD420261456447). Random\u2010effects meta\u2010analysis pooled mean differences (MDs) and risk ratios (RRs) with 95% CIs; heterogeneity, subgroup, sensitivity, GRADE and publication bias analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen RCTs were included. Dual agonists significantly reduced absolute body weight (MD: \u22126.65\u2009kg, moderate certainty), relative weight (MD: \u22127.15%), and increased likelihood of \u2265\u20095% weight loss (RR: 4.75, low certainty), with mazdutide and survodutide showing the largest effects. Significant improvements occurred in HbA1c, BMI, waist circumference, systolic blood pressure and triglycerides. Any adverse events were more frequent with dual agonists (RR: 1.16), while serious adverse events did not differ from controls (RR: 0.90, high certainty).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dual GLP\u20101\/GCGR agonists produce meaningful weight loss and metabolic improvements with acceptable short\u2010term safety, though longer head\u2010to\u2010head trials are needed to confirm durability and cardiovascular safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71400","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:43:36Z","timestamp":1790739816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Dual\n                    <scp>GLP<\/scp>\n                    \u20101\/Glucagon Receptor Agonism in Overweight and Obesity: A Class\u2010Specific Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9252-1979","authenticated-orcid":false,"given":"Muhammad Maaz","family":"Amjad","sequence":"first","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Mustafa","family":"Khan","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Watim Medical and Dental College  Rawat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqsa","family":"Ali","sequence":"additional","affiliation":[{"name":"Federal Medical College  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maham","family":"Ali","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University  Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiza","family":"Bakhash","sequence":"additional","affiliation":[{"name":"Federal Medical College  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humna","family":"Abid","sequence":"additional","affiliation":[{"name":"Watim Medical and Dental College  Rawat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Isra University  Hyderabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashaf","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Isra University  Hyderabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dur\u2010e\u2010Najaf","family":"Ali","sequence":"additional","affiliation":[{"name":"Shahida Islam Medical and Dental College  Lodhran Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9965-340X","authenticated-orcid":false,"given":"Malik Muhammad Nasr","family":"Fayyaz","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Hassan","sequence":"additional","affiliation":[{"name":"Khyber Girls Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safwan Masaud","family":"Mian","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar 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