{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:55:55Z","timestamp":1790654155061,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Obesity is a complication of childhood craniopharyngioma that remains difficult to treat. We investigated whether semaglutide was associated with a decrease in BMI among adolescents with craniopharyngioma\u2010related obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This multicentre retrospective study included 20 patients &lt;\u200918\u2009years old with craniopharyngioma and obesity (BMI &gt;\u20092 WHO\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score) from 2019 to 2024 (source population: 139 children with craniopharyngioma, including 36 children with obesity). They received off\u2010label semaglutide with dose titration (0.25\u20132\u2009mg\/week), tailored to tolerance and clinical response. The primary outcome was the within\u2010patient comparison of BMI change from \u221212\u2009months to treatment initiation and from initiation to +12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At semaglutide initiation, patients were 14.0\u2009\u00b1\u20093.9\u2009years old, the interval since craniopharyngioma diagnosis was 6.3\u2009\u00b1\u20094.7\u2009years, and BMI was 33.4\u2009\u00b1\u20093.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (3.2\u2009\u00b1\u20090.7\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score). Tumour treatment was surgery alone (8\/20), surgery and proton therapy (11\/20), or proton therapy alone (1\/20). All patients had growth hormone and TSH deficiency; 19\/20 had ACTH and AVP deficiency. In the year before treatment, patients gained 3.5\u2009\u00b1\u20094.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in BMI and 0.6\u2009\u00b1\u20091.6 in BMI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score; after 1\u2009year of semaglutide therapy, they lost 2.5\u2009\u00b1\u20093.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in BMI and 0.5\u2009\u00b1\u20090.5 in BMI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score (paired comparisons,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004, respectively). During treatment, BMI decreased by 10% or more in 40% of patients (95% CI: 19%\u201364%). Gastrointestinal side effects occurred in 30% of patients but were mild. No cases of treatment discontinuation, pituitary insufficiency decompensation or tumour recurrence were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide was associated with reversal of weight gain among adolescents with craniopharyngioma\u2010related obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71403","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:11:49Z","timestamp":1790651509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Semaglutide for Treating Paediatric Craniopharyngioma\u2010Related Obesity: A Multicentre Case Series"],"prefix":"10.1111","author":[{"given":"Joanne","family":"Dornberger","sequence":"first","affiliation":[{"name":"Endocrine, Bone Diseases and Genetics Unit Children's Hospital, Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Barat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology CHU Bordeaux  Bordeaux France"},{"name":"Reference Center for Rare Obesity CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Aouchiche","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Assistance Publique\u2010H\u00f4pitaux de Marseille  Marseille France"},{"name":"Reference Center for Rare Pituitary Diseases  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Perge","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Civil Hospices of Lyon  Lyon France"},{"name":"Reference Center for Rare Pituitary Diseases Civil Hospices of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Civil Hospices of Lyon  Lyon France"},{"name":"Reference Center for Rare Pituitary Diseases Civil Hospices of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Castets","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Assistance Publique\u2010H\u00f4pitaux de Marseille  Marseille France"},{"name":"Reference Center for Rare Pituitary Diseases  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Bouhours\u2010Nouet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University Hospital  Angers France"},{"name":"Reference Center for Rare Pituitary Diseases University Hospital  Angers 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de Paris  Paris France"},{"name":"Reference Center for Rare Disease of Growth and Development (CRESCENDO)  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulanjalee","family":"Kariyawasam","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Disease of Growth and Development (CRESCENDO)  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Pediatric Endocrinology, Diabetology, Gynecology Department Necker\u2013Enfants Malades University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-4243","authenticated-orcid":false,"given":"Regis","family":"Coutant","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology University Hospital  Angers France"},{"name":"Reference Center for Rare Pituitary Diseases University Hospital  Angers 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