{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:55:16Z","timestamp":1791881716373,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular disease and chronic kidney disease are the principal drivers of morbidity and mortality in type 2 diabetes mellitus (T2DM). Sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2i) have demonstrated cardiorenal benefits in landmark trials, yet cross\u2010trial inconsistencies in cardiovascular mortality, renal endpoints and drug\u2010specific effects leave the class\u2010level estimates incompletely synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, Scopus and CENTRAL were searched from inception through 15 May 2026. Large placebo\u2010controlled RCTs (\u2265\u20091000 participants) and prespecified subgroup analyses in adults with T2DM were eligible. The primary outcome was the composite of first hospitalization for heart failure (HHF) or cardiovascular death (CV death). Secondary outcomes were 3\u2010point major adverse cardiovascular events (MACE), CV DEATH, myocardial infarction (MI), stroke, first HHF and composite kidney outcomes. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using random\u2010effects inverse\u2010variance models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies (76\u2009969 patients; 41\u2009761 SGLT2i, 35\u2009208 placebo) were included. SGLT2i reduced the primary composite by 23% (HR: 0.77, 95% CI: 0.73\u20130.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), with no effect modification by baseline HF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010interaction\u2009=\u20090.82) or established ASCVD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010interaction\u2009=\u20090.46). MACE was reduced by 14% (HR: 0.86, 95% CI: 0.81\u20130.92), driven by significant reductions in CV DEATH (HR: 0.86, 95% CI: 0.79\u20130.93) and MI (HR: 0.88, 95% CI: 0.81\u20130.96), with no significant effect on stroke (HR: 0.93, 95% CI: 0.81\u20131.08). First, HHF was reduced by 29% (HR: 0.71, 95% CI: 0.66\u20130.77) and composite kidney outcomes by 31% (HR: 0.69, 95% CI: 0.60\u20130.79).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2i confer consistent and clinically meaningful cardiorenal protection in T2DM across the full spectrum of cardiovascular and renal risk. The ertugliflozin estimate and the moderate heterogeneity in kidney outcomes should be interpreted in the context of trial\u2010level clinical differences and nonstandardized kidney endpoint definitions. These findings support proactive, guideline\u2010concordant initiation of evidence\u2010based SGLT2i agents by endocrinologists, cardiologists and primary care providers as foundational therapy in T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71411","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:36:26Z","timestamp":1791880586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SGLT2<\/scp>\n                    Inhibitors Reduce Heart Failure Hospitalization, Cardiovascular Death and Kidney Outcomes in Type 2 Diabetes: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","author":[{"given":"Ahmed","family":"Elbataa","sequence":"first","affiliation":[{"name":"Faculty of Medicine Al\u2010Azhar University  Cairo 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