{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:55:28Z","timestamp":1791248128693,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>CONFIDENCE evaluated simultaneous initiation of finerenone and an SGLT2 inhibitor (SGLT2i). We examined 12\u2010month trajectories of albuminuria and non\u2010albumin proteinuria after finerenone was added to established SGLT2i therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This single\u2010centre retrospective cohort study included 86 patients with type 2 diabetes treated with finerenone after SGLT2i therapy. Urinary albumin\u2010to\u2010creatinine ratio (UACR), protein\u2010to\u2010creatinine ratio (UPCR) and non\u2010albumin protein\u2010to\u2010creatinine ratio (UNAPCR) were measured before SGLT2i initiation (T1) and finerenone initiation (T2), at the first post\u2010finerenone assessment (median 1.6\u2009months), and at 6 and 12\u2009months. Covariate\u2010adjusted linear mixed\u2010effects models of log\u2010transformed markers estimated geometric mean changes from T2, with Holm adjustment across 12 primary contrasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Urinary markers showed no significant net changes between T1 and T2. After finerenone initiation, UACR decreased by 46.2% at the first post\u2010finerenone assessment and remained 35.2% lower at 12\u2009months (95% confidence interval [CI], \u221247.1 to \u221220.7); corresponding reductions were 39.9% and 23.1% for UPCR and 33.7% and 13.6% for UNAPCR. All reductions were significant except for UNAPCR at 12\u2009months (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16). At 12\u2009months, 39 of 76 patients (51.3%) achieved a UACR reduction \u2265\u200930%. Mean serum potassium level increased from 4.6 to 4.8\u2009mmol\/L and plateaued; levels &gt;\u20095.5 and &gt;\u20096.0\u2009mmol\/L occurred in 17.4% and 4.7% of patients, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with residual albuminuria despite established SGLT2i therapy, finerenone addition was associated with sustained 12\u2010month reductions in albuminuria and total proteinuria and an early reduction in non\u2010albumin proteinuria that attenuated by 12\u2009months. Prospective confirmation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71412","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:31:46Z","timestamp":1791246706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trajectories of Albuminuria and Non\u2010Albumin Proteinuria After Sequential Addition of Finerenone for Residual Albuminuria Despite Established\n                    <scp>SGLT2<\/scp>\n                    Inhibitor Therapy in Diabetic Kidney Disease: A Real\u2010World Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2605-8549","authenticated-orcid":false,"given":"Min Seo","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minheui","family":"Yu","sequence":"additional","affiliation":[{"name":"SENTINEL Team, Division of Endocrinology, Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Kidney Disease Research Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-7512","authenticated-orcid":false,"given":"Minyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-4942","authenticated-orcid":false,"given":"Yong\u2010ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-4675","authenticated-orcid":false,"given":"Eun Seok","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-2854","authenticated-orcid":false,"given":"Bong\u2010Soo","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-4992","authenticated-orcid":false,"given":"Byung\u2010Wan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of 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